Implantable myocardial ischemia detection, indication and action technology
First Claim
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1. A method comprising:
- monitoring the heart for evidence of myocardial ischemia/infarction (MI/I) using a device implanted into a subject;
alerting the subject upon detection of MI/I using a signal generated by the implanted device and transmitted to the subject.
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Abstract
One embodiment enables detection of MI/I and emerging infarction in an implantable system. A plurality of devices may be used to gather and interpret data from within the heart, from the heart surface, and/or from the thoracic cavity. The apparatus may further alert the patient and/or communicate the condition to an external device or medical caregiver. Additionally, the implanted apparatus may initiate therapy of MI/I and emerging infarction.
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Citations
148 Claims
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1. A method comprising:
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monitoring the heart for evidence of myocardial ischemia/infarction (MI/I) using a device implanted into a subject;
alerting the subject upon detection of MI/I using a signal generated by the implanted device and transmitted to the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 21, 22, 23, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 53, 54, 55, 56, 58, 60, 63, 64, 65, 66, 67, 70, 74)
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8. A method for monitoring the heart of a subject for MI/I inside of the subject, comprising:
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implanting into a subject'"'"'s chest a container including circuitry and a microprocessor;
providing a plurality of sensors electrically connected to the circuitry;
positioning at least one sensor in or on the heart of the subject; and
determining whether MI/I has occurred. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 68, 69, 71, 72, 73, 75)
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24. A method for monitoring a heart in a subject for evidence of MI/I comprising:
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implanting a container including circuitry and a microprocessor in the subject; and
providing a plurality of leads extending from the container, wherein at least one lead extends to a position inside of the heart.
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- 44. A method for monitoring electrogram signals, comprising sensing changes in depolarization resulting from MI/I.
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46. A method for monitoring electrogram signals, comprising sensing changes in combined depolarization and repolarization and determining whether a MI/I has occurred.
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47. A method of detecting a myocardial ischemia signal in a subject, comprising analyzing an electrogram signal by determining its temporal features synchronous to the Q, R, S, and T waves in a surface ECG signal.
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57. A method for distinguishing normal and ischemic sensor information comprising analyzing temporal and spectral sensor signals derived from a plurality of sensors implanted in a subject.
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59. A method for monitoring a subject for MI/I, wherein a pacemaker is connected to the subject'"'"'s heart, the method comprising:
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analyzing a paced electrogram signal;
monitoring MI/I related to changes during a depolarization event in the paced electrogram signal; and
monitoring MI/I related to changes during a repolarization event in the paced electrogram signal.
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61. A method for reading, storing and relaying information from an apparatus implanted in a subject, the information being relating to a MI/I event in the subject, the method comprising:
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providing a plurality of analog signals relating to the myocardial event to circuitry connected to a analog to digital converter controlled by a microprocessor implanted in a subject;
converting the analog signals to digital data;
storing the digital data in a memory of the microprocessor;
recording the digital data into a continuous loop in the memory and overwriting old data therein;
recovering stored MI/I information; and
transmitting the stored MI/I information to an external device as an electromagnetic code. - View Dependent Claims (62)
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76. A method for treating a subject comprising:
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implanting a device in the subject;
detecting MI/I using the device;
initiating a therapy in the subject based on a signal generated by the device. - View Dependent Claims (77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 90, 91, 92, 93)
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- 87. A method of manufacturing an implantable device elected from the group consisting of pacemakers, cardio-defibrillators, atrial defibrillators, ventrical defibrillators, cardiac assist devices, and drug infusion devices, the method including the steps of incorporating circuitry for monitoring the occurrence of a MI/I in a subject and providing a signal indicating the occurrence of a MI/I.
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94. An apparatus for detecting MI/I in a subject, comprising:
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an implantable container;
at least one lead adapted for insertion into the heart;
at least one sensor adapted for insertion into the heart; and
a microprocessor in the container to analyze data from the at least one sensor. - View Dependent Claims (95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 130, 132, 135, 136, 137, 139, 140, 141, 143, 144, 146, 147, 148)
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117. An implantable apparatus for monitoring a subject for MI/I comprising:
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a hermetically sealed container;
circuitry disposed within the container;
an analog to digital converter disposed within the container;
a logic device disposed within the container; and
a feed-through interface between at least one lead extending from the container and the circuitry.
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129. An apparatus for determining the location of a myocardial ischemic event comprising an implantable device including a plurality of sensors adapted to be positioned in various locations in and on the heart, the device further including means for analyzing the changes in electrogram signals received from the sensors.
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131. An apparatus for recording and storing MI/I information, comprising:
an implantable device comprising;
means for digitizing electrogram signals means for storing the signals;
means for recording the digitized electrogram signals in memory;
means for recovering the digitized electrogram signals in memory; and
means for transmitting a signal from the apparatus to an external source.
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133. An apparatus for detecting MI/I in a subject, comprising:
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means for detecting MI/I; and
means for generating a signal to alert the subject about the MI/I;
wherein the means for detecting and the means for generating the signal are implanted in the subject.
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134. An apparatus for detecting MI/I in a subject, comprising:
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an implantable container;
at least one lead adapted for insertion into the heart and electrically connected to circuitry in the container;
at least one sensor coupled to the at least one lead and adapted for insertion into the heart;
a microprocessor in the container to analyze data from the at least one sensor; and
a transmitter.
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138. An implantable apparatus for detecting and treating MI/I in a subject, comprising:
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a container;
at least one lead adapted for insertion in the user and electrically connected to circuitry in the container;
at least one sensor coupled to the at least one lead;
a logic device in the container to analyze data from the at least one sensor; and
a supply of at least one drug to treat MI/I.
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142. An implantable apparatus for detecting and treating MI/I in a subject, comprising:
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a container;
a plurality of leads electrically connected to circuitry in the container;
a plurality of sensors coupled to the plurality of leads;
a logic device in the container to analyze data from the plurality of leads; and
means for treating the subject in response to a determination that a MI/I has occurred.
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145. An implantable apparatus for detecting and treating MI/I in a subject, comprising:
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a plurality of sensors coupled to the plurality of leads, wherein at least one sensor is adapted for placement in or on the subject'"'"'s heart; and
a logic device to analyze data from the plurality of leads and determine if a MI/I has occurred.
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Specification