Drug delivery device and method

• US 20030014014A1
• Filed: 08/06/2002
• Published: 01/16/2003
• Est. Priority Date: 02/10/2000
• Status: Abandoned Application

• Current Assignee: Power Paper Ltd. (Products To Go, Inc.)
• Original Assignee: Power Paper Ltd. (Products To Go, Inc.)
• Inventors: Nitzan, Zvi
• Application Number:
  US10/203,101
• Publication Number:
  US 20030014014A1
• Time in Patent Office: Days
• US Class Current: 604/158
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3576 with non implanted data transmission devices, e.g. using external transmitter or receiver
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/1422 with double acting or multiple pistons
• CPC Class Codes: A61M 5/14248 of the skin patch type

Abstract

A drug delivery device for delivering a predetermined drug dose to a body region of an individual, the drug delivery device comprising (a) a reservoir being for containing a liquid preparation of a drug; (b) a drug delivery element being for delivery of the liquid preparation into the body region; and (c) a drug delivery mechanism being capable of fluid communication with one of the reservoir and the drug delivery element at a given time, such that when activated, the drug delivery mechanism cycles through a mode of acquisition of a quantity of the liquid preparation from the reservoir and a subsequent mode of expulsion of the quantity of the liquid preparation acquired from the reservoir, through the drug delivery element into the body region, wherein the predetermined drug dose is delivered by a predetermined number of the cycles.

Claims

1. A drug delivery device for delivering a predetermined drug dose to a body region of an individual, the drug delivery device comprising:

(a) a reservoir being for containing a liquid preparation of a drug;

(b) a drug delivery element being for delivery of said liquid preparation into the body region;

(c) a drug delivery mechanism being capable of fluid communication with one of said reservoir and said drug delivery element at a given time, such that when activated, said drug delivery mechanism cycles through a mode of acquisition of a quantity of said liquid preparation from said reservoir and a subsequent mode of expulsion of said quantity of said liquid preparation acquired from said reservoir, through said drug delivery element into the body region, wherein the predetermined drug dose is delivered by a predetermined number of said cycles.

2. A skin patch for delivering a predetermined drug dose to a subcutaneous region of an individual, the skin patch comprising:

(a) a skin attachment element being for attaching the skin patch to a skin region of the individual;

(b) a reservoir being connected to or integrally formed with said skin attachment element for containing a liquid preparation of a drug;

(c) a needle element being held by said skin attachment element and being dimensioned for delivery of said liquid preparation into the subcutaneous region;

(d) a drug delivery mechanism being capable of fluid communication with one of said reservoir and said needle element at a given time, such that when activated, said drug delivery mechanism cycles through a mode of acquisition of a quantity of said liquid preparation from said reservoir and a subsequent mode of expulsion of said quantity of said liquid preparation acquired from said reservoir, through said needle element into the subcutaneous region, wherein the predetermined drug dose is delivered by a predetermined number of said cycles.

3. The skin patch of claim 2, further comprising a power source being for powering said drug delivery mechanism.

4. The skin patch of claim 2, further comprising a control unit being for controlling said drug delivery mechanism.

5. The skin patch of claim 4, further comprising a user interface communicating with said control unit.

6. The skin patch of claim 2, further comprising a data transmitting assembly being in communication with said reservoir, said data transmitting assembly being for acquiring and transmitting to a remote device, data pertaining to the status of said liquid preparation in said reservoir.

7. The skin patch of claim 6, wherein said data transmitting assembly also communicates with said drug delivery mechanism and as such, said data transmitted from said data transmitting assembly also includes information pertaining to an operational status of said drug delivery mechanism.

8. The skin patch of claim 2, wherein said drug delivery mechanism includes a pump capable of acquiring said quantity of said liquid preparation from said reservoir and expelling said quantity of said liquid preparation acquired from said reservoir, through said needle element.

9. The skin patch of claim 8, wherein said pump includes a plunger connected to an actuator, said actuator being for translating said plunger in a first direction for acquiring said quantity of said liquid preparation from said reservoir, and in a second direction for expelling said quantity of said liquid preparation acquired from said reservoir, through said needle element.

10. The skin patch of claim 9, wherein said actuator includes a gas generating cell provided with an elastic membrane, such that when said cell generates gas, said membrane expands to translate said plunger in one of said first and said second directions, and when said gas is released from said cell, said plunger is translated in another of said first and said second directions.

11. The skin patch of claim 10, wherein said gas generating cell includes a zinc-air power cell capable of generating hydrogen gas.

12. The skin patch of claim 9, wherein said actuator includes a gas consuming cell provided with an elastic membrane, such that when said cell consumes gas, said membrane is displaced to translate said plunger in one of said first and said second directions, and when said gas is released from said cell, said plunger is translated in another of said first and said second directions.

13. The skin patch of claim 12, wherein said gas consuming cell includes a zinc-air power cell capable of reacting with oxygen gas.

14. The skin patch of claim 2, wherein said drug delivery mechanism further includes a switching device being for determining which of said reservoir and said needle element are in fluid communication with said drug delivery mechanism at said given time.

15. The skin patch of claim 14, wherein said switching device further serves for determining said mode of said drug delivery mechanism according to said fluid communication thereof at said given time.

16. The skin patch of claim 15, wherein said switching device includes a plunger connected to an actuator, said actuator being for translating said plunger in a first direction or in a second and opposing direction.

17. The skin patch of claim 2, wherein said skin attachment element includes an adhesive.

18. The skin patch of claim 2, wherein said needle element is composed of a material selected from the group consisting of stainless steel, carbon fiber, polypropylene and polyurethane.

19. The skin patch of claim 2, wherein said needle element includes a plurality of individual micro needles.

20. The skin patch of claim 2, wherein said needle element is capable of being positioned in or out of said subcutaneous region when said skin attachment element is attached to said skin region.

21. A method of delivering a predetermined drug dose to a body region of an individual, the method comprising the steps of:

(a) positioning a needle element within the body region;

(b) providing a reservoir being for containing a liquid preparation of a drug;

(c) providing a drug delivery mechanism being capable of fluid communication with one of said reservoir and said needle element at a given time; and

(d) cycling said drug delivery mechanism through a mode of acquisition of a quantity of said liquid preparation from said reservoir and a subsequent mode of expulsion of said quantity of said liquid preparation acquired from said reservoir, through said needle element into the body region, wherein the predetermined drug dose is delivered by a predetermined number of said cycles.

22. The method of claim 21, wherein said needle element, said reservoir and said drug delivery mechanism are integrated within a drug delivery skin patch.