Reservoir device for intraocular drug delivery
First Claim
1. A sustained release delivery device for delivering an agent to the interior of a patient'"'"'s eye, comprising:
- a reservoir having a proximal end and a distal end;
an inlet port near the proximal end of the reservoir for injection of an agent into the reservoir; and
a delivery mechanism for delivering the agent from the reservoir to the interior of a patient'"'"'s eye at a desired rate.
1 Assignment
0 Petitions
Accused Products
Abstract
A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
-
Citations
52 Claims
-
1. A sustained release delivery device for delivering an agent to the interior of a patient'"'"'s eye, comprising:
-
a reservoir having a proximal end and a distal end;
an inlet port near the proximal end of the reservoir for injection of an agent into the reservoir; and
a delivery mechanism for delivering the agent from the reservoir to the interior of a patient'"'"'s eye at a desired rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 37, 40, 41, 42, 43, 46, 50, 52)
-
-
19. A sustained release delivery device for delivering an agent to a patient, comprising:
-
a hollow body having a proximal end and a distal end;
an inlet port at the proximal end of the hollow body for injection of the agent;
a pliable reservoir covering at least a portion of the hollow body;
at least one aperture in the hollow body for providing communication between the hollow body and the reservoir;
a delivery mechanism for delivering the agent to the patient, the delivery mechanism in communication with the reservoir whereby therapeutic agent is injected through the inlet port and travels into the reservoir and, whereby upon closure of the inlet port, the therapeutic agent flows out of the reservoir through the delivery mechanism at a desired rate. - View Dependent Claims (32, 33, 34, 35, 36, 38, 39)
-
-
20. The delivery device of 19, wherein the distal end of the hollow body extends outside the reservoir and comprises the delivery mechanism.
- 44. A sustained release delivery device that utilizes the elastomeric properties of a reservoir housing an agent to deliver the agent from the reservoir to a treatment site at a desired rate.
-
45. A sustained release delivery device comprising
a reservoir fabricated of an elastomeric material, the reservoir having a proximal end and a distal end; -
an inlet port near the proximal end of the reservoir for injection of an agent into the reservoir; and
a delivery mechanism for delivering the agent from the reservoir to the interior of a patient'"'"'s eye at a desired rate, whereby the delivery device utilizes the elastomeric properties of the reservoir to deliver the agent at a desired rate.
-
-
48. A method for sustained delivery of an agent, the method comprising the steps of:
-
(a) providing a sustained release delivery device comprising;
a pliable reservoir having a proximal end and a distal end, the reservoir being empty;
an inlet port near the proximal end of the reservoir for injection of an agent into the reservoir; and
a delivery mechanism for delivering the agent from the reservoir to the patient;
(b) making an incision in the patient to access the treatment area;
(c) compressing the pliable reservoir for insertion;
(d) inserting the delivery device into the treatment area through the incision such that the inlet port remains outside the incision;
(e) using an injection mechanism to inject the agent through the inlet port;
(f) allowing the therapeutic agent to flow into the reservoir;
(g) removing the injection mechanism from the inlet port and closing off the inlet port;
(h) allowing the therapeutic agent to travel out of the reservoir and to the patient through the delivery mechanism;
(i) optionally repeating steps (c) through (h) one or more times; and
(j) removing the delivery device from the treatment area.
-
-
49. A method for sustained delivery of an agent, the method comprising the steps of:
-
(a) providing a sustained release delivery device comprising;
a hollow body having a proximal end and a distal end;
an inlet port at the proximal end of the hollow body for injection of the agent;
a pliable reservoir covering at least a portion of the hollow body, the reservoir being empty;
at least one aperture in the hollow body for providing communication between the hollow body and the reservoir;
a delivery mechanism for delivering the agent in the reservoir to the patient;
(b) making an incision in the patient to access the treatment area;
(c) compressing the pliable reservoir about the hollow body for insertion;
(d) inserting the delivery device into the treatment area through the incision such that the inlet port remains outside the incision;
(e) using an injection mechanism to inject the therapeutic agent through the inlet port;
(f) allowing the therapeutic agent to flow through the hollow body, through the at least one aperture in the hollow body and into the reservoir;
(g) removing the injection mechanism from the inlet port and closing off the inlet port;
(h) allowing the therapeutic agent to travel out of the reservoir and to the patient through the a delivery mechanism;
(i) optionally repeating steps (c) through (h) one or more times; and
(j) removing the delivery device from the treatment area.
-
-
51. A method for sustained delivery of an agent comprising utilizing the elastomeric properties of a reservoir housing the agent to deliver the agent from the reservoir to a treatment site at a desired rate.
Specification