Multiple-site sample-handling apparatus and method
First Claim
1. A microchannel sample-handling apparatus for processing a sample, comprising (a) a microchannel device having (i) a substrate, (ii) an elongate or planar multisite reaction channel formed in said substrate for receiving a bulk-phase medium containing sample components, said reaction channel having a plurality of reaction regions and region-specific reagents associated with each region, for simultaneously conducted different reactions on sample components within the reaction channel, (iii) one or more sample-preparation stations in said substrate, upstream of said reaction channel, for carrying out one or more selected sample-preparation steps effective to convert a sample to such bulk-phase medium, and (iv) one or more product-processing stations downstream of said reaction channel, for processing products generated in one or more of said reaction regions, means for transferring solvent or solvent components between one of said sample-preparation stations and one or more selected reaction regions in the reaction channel, and between one or more selected reaction regions in the reaction channel and one of said product-processing stations, and a control unit for activating said transfer means, to effect transfer, in a selected reaction region, of solvent or solvent components from or to each hold or region-specific reservoir, to or from the associated reaction region.
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Abstract
A microchannel apparatus and method for processing a sample are disclosed. The apparatus include a multisite reaction channel, one or more sample-preparation stations upstream of the reaction channel, for carrying out one or more selected sample-preparation steps effective to convert a sample to the bulk-phase medium, and one or more product-processing stations downstream of the reaction channel, for processing products generated in one or more of the reaction regions. Also included is structure for transferring solvent or solvent components between one of the sample-preparation stations and one or more selected reaction regions in the reaction channel, and between one or more selected reaction regions in the reaction channel and one of said product-processing stations, under the control of a control unit.
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Citations
14 Claims
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1. A microchannel sample-handling apparatus for processing a sample, comprising
(a) a microchannel device having (i) a substrate, (ii) an elongate or planar multisite reaction channel formed in said substrate for receiving a bulk-phase medium containing sample components, said reaction channel having a plurality of reaction regions and region-specific reagents associated with each region, for simultaneously conducted different reactions on sample components within the reaction channel, (iii) one or more sample-preparation stations in said substrate, upstream of said reaction channel, for carrying out one or more selected sample-preparation steps effective to convert a sample to such bulk-phase medium, and (iv) one or more product-processing stations downstream of said reaction channel, for processing products generated in one or more of said reaction regions, means for transferring solvent or solvent components between one of said sample-preparation stations and one or more selected reaction regions in the reaction channel, and between one or more selected reaction regions in the reaction channel and one of said product-processing stations, and a control unit for activating said transfer means, to effect transfer, in a selected reaction region, of solvent or solvent components from or to each hold or region-specific reservoir, to or from the associated reaction region.
Specification