Molecules that influence pathogen resistance
First Claim
1. A method of modifying an anti-microbial immune response in a subject, comprising modifying an IGIP-family protein activity in the subject to enhance or inhibit the immune response.
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Abstract
The functions of IFNγ-induced GTPases of the IGTP-family as strong anti-infective agents, and more particularly a strong anti-parasite and/or anti-bacterial agents, are disclosed. These molecules (in both protein and nucleic acid forms) are effective to modify anti-microbial e.g., anti-bacterial and/or anti-parasitic) immune responses in a subject, to prevent or inhibit replication or infectivity of microbe, to treat microbial diseases, and to detect susceptibility of a subject to microbial infection. This invention also provides kits and compounds useful in such methods. Also provided are transgenic non-human animals in which IGTP-family member gene expression has been altered, and the use of such animals to screen for anti-microbial agents.
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Citations
61 Claims
- 1. A method of modifying an anti-microbial immune response in a subject, comprising modifying an IGIP-family protein activity in the subject to enhance or inhibit the immune response.
- 43. A transgenic non-human animal in which IGTP-family member gene expression has been altered.
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52. A pharmaceutical composition comprising:
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a pharmaceutically acceptable vehicle or carrier a therapeutically effective amount of at least one anti-microbial compound; and
a therapeutically effective amount of at least one IGTP-family protein, or a fragment, variant, analog or mimetic thereof, or a nucleic acid that encodes an IGTP-family protein, fragment, variant, analog, derivative mimetic thereof. - View Dependent Claims (53, 54, 55, 56, 57, 58, 59, 60, 61)
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Specification