Treatment of ocular disease
First Claim
1. A method to treat a diseased eye in a patient comprising intraocularly administering to the patient a composition consisting essentially of tacrolimus in a pharmaceutically acceptable formulation and in an amount effective to treat the diseased eye without substantial toxicity to the patient.
3 Assignments
0 Petitions
Accused Products
Abstract
A formulation to treat ocular disease such as dry eye disease, as well as other diseases, is disclosed. Tacrolimus is administered intraocularly, such as topically or by injection. For topical administration, an amount of about 1 ng to 10 μg may be formulated in an aqueous based cream that may be applied at bedtime or throughout the day. For injection, a dose of about 20-1000 μg/ml is used. Tacrolimus may also be administered in milligram quantities as a surgical implant contained in a diffusible walled reservoir sutured to the wall of the sclera, or may be contained within an inert carrier such as microspheres or liposomes to provide a slow-release drug delivery system.
89 Citations
30 Claims
- 1. A method to treat a diseased eye in a patient comprising intraocularly administering to the patient a composition consisting essentially of tacrolimus in a pharmaceutically acceptable formulation and in an amount effective to treat the diseased eye without substantial toxicity to the patient.
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16. A method to treat a diseased eye in a patient comprising intraocularly administering to the patient a composition consisting essentially of tacrolimus in a pharmaceutically acceptable formulation and in an amount effective to treat the diseased eye.
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25. A therapeutic composition for treating a diseased eye consisting essentially of tacrolimus in a physiologically acceptable intraocular formulation and in an amount effective to treat the diseased eye without substantial toxicity to the eye.
Specification