Valency platform molecules comprising carbamate linkages
First Claim
1. A compound having the structure of one of the following formulae:
0 Assignments
0 Petitions
Accused Products
Abstract
This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate. More particularly, the present invention pertains to valency platform molecules which comprise a carbamate linkage (i.e., —O—C(═O)—N<). In one aspect, the present invention pertains to valency platforms comprising carbamate linkages, which molecules have the structure of any one of Formulae I, II, or III, shown in FIG. 1. In one aspect, the present invention pertains to valency platforms comprising carbamate linkages, which molecules have the structure of any one of Formulae IV, V, or VI, shown in FIG. 8. The present invention also pertains to methods of preparing such valency platform molecules, conjugates comprising such valency platform molecules, and methods of preparing such conjugates.
-
Citations
46 Claims
- 1. A compound having the structure of one of the following formulae:
-
19. A compound having the structure of one of the following formulae:
-
38. A composition comprising valency platform molecules, wherein each said valency platform molecule comprises at least 2 carbamate linkages and at least 4 reactive conjugating functional groups;
- and
wherein said valency platform molecules have a polydispersity less than about 1.2.
- and
-
44. A composition comprising valency molecules, wherein each said valency molecule comprises at least two branches and at least four terminal groups;
-
wherein each said valency molecule comprises at least 2 carbamate linkages; and
wherein said valency molecules have a polydispersity less than about 1.2. - View Dependent Claims (45, 46)
-
Specification