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Biological modeling utilizing image data

  • US 20030018457A1
  • Filed: 03/11/2002
  • Published: 01/23/2003
  • Est. Priority Date: 03/13/2001
  • Status: Abandoned Application
First Claim
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1. A method for quantitative or semi-quantitative modeling of a biological or physiological system, said method comprising the steps of:

  • a. acquiring time-series image data relating to said biological or physiological system;

    b. generating a prediction of the dynamic evolution of the state of said biological or physiological system using a simulation model that takes into account underlying physiological, chemical or biological variables;

    c. converting said biological- or physiological-state prediction into a series of predicted images corresponding temporally to the acquired images; and

    d. modifying the simulation model in such a manner as to reduce the magnitude of an error measure that is based upon the differences between the acquired time-series image data and the predicted images.

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