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Method for screening crystallization conditions in solution crystal growth

  • US 20030022384A1
  • Filed: 05/30/2002
  • Published: 01/30/2003
  • Est. Priority Date: 04/06/1999
  • Status: Active Grant
First Claim
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1. A method of screening protein crystal growth conditions employing picogram, nanogram or to microgram amounts of protein comprising the steps of:

  • providing a microarray with a plurality of wells in said microarray;

    accurately dispensing a volume of from about 0.001 nl to about 250 nl of a protein solution into said wells;

    controlling the protein crystal growth conditions of each of said wells so that the protein crystal growth conditions in at least two of said micro-chambers differs; and

    observing protein crystal growth or protein precipitation in said wells.

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