Use of GLP-1 or analogs in treatment of myocardial infarction

• US 20030022823A1
• Filed: 04/12/2001
• Published: 01/30/2003
• Est. Priority Date: 08/30/1996
• Status: Active Grant

• Current Assignee: Spadina Bloor LP
• Original Assignee: Suad Efendic
• Inventors: Efendic, Suad
• Granted Patent: US 6,747,006 B2
• Time in Patent Office: Days
• US Class Current: 514/12
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

This invention provides a method of reducing mortality and morbidity after myocardial infarction. GLP-1, a GLP-1 analog, or a GLP-1 derivative, is administered at a dose effective to normalize blood glucose.

Claims

1. A method of reducing mortality and morbidity after myocardial infarction, comprising administering to a patient in need thereof, a compound selected from the group consisting of GLP-1, GLP-1 analogs, GLP-1 derivatives, and pharmaceutically-acceptable salts thereof, at a dose effective to normalize blood glucose.

2. The method of claim 1, wherein the compound is administered intravenously.

3. The method of claim 1, wherein the compound is administered subcutaneously.

4. The method of claims 2 or 3, wherein the administration is continuous.

5. The method of claim 4 wherein the rate of administration of the compound is between 0.25 and 6 pmol/kg/h.

6. The method of claim 5 wherein the rate of administration of the compound is between 0.6 and 2.4 pmol/kg/h.

7. The method of claims 2 or 3 wherein the intravenous administration is intermittent.

8. The method of claim 2 wherein the compound is administered intravenously and also administered by another parenteral route.

9. The method of claim 8 wherein the other parenteral route is the subcutaneous route.

10. The method of claim 1 wherein the compound administered is GLP(7-36) amide, or a pharmaceutically-acceptable salt thereof.

11. A method of reducing morbidity and mortality after myocardial infarction, comprising, administering a compound that exerts insulinotropic activity by interacting with the same receptor, or receptors, with which GLP-1, GLP-1 analogs, and GLP-1 derivatives interact in exerting their insulinotropic activity.

12. A method of reducing morbidity and mortality after myocardial infarction, comprising, administering a compound that enhances insulin sensitivity by interacting with the same receptor, or receptors, with which GLP-1, GLP-1 analogs, and GLP-1 derivatives interact to enhance insulin sensitivity.