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Compositions and methods for enhancing drug delivery across and into ocular tissues

  • US 20030022831A1
  • Filed: 02/25/2002
  • Published: 01/30/2003
  • Est. Priority Date: 08/24/1999
  • Status: Active Grant
First Claim
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1. A method for enhancing delivery of a compound into and across an animal ocular tissue, the method comprising:

  • administering to the ocular tissue a conjugate comprising the compound and a delivery-enhancing transporter, wherein;

    i. the compound is attached to the delivery-enhancing transporter through a linker, and ii. the delivery-enhancing transporter comprises fewer than 50 subunits and comprises at least 5 guanidino or amidino moieties, thereby increasing delivery of the conjugate into the ocular tissue compared to delivery of the compound in the absence of the delivery-enhancing transporter.

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