Targeted interference subtraction applied to near-infrared measurement of analytes
First Claim
1. An apparatus for modeling and removing targeted interfering signals from spectral measurements comprising:
- means for measuring a spectrum of a sample; and
at least one interference model, wherein said interference is approximately orthogonal to an analyte signal of interest, said interference model adapted to remove spectral interference from said measured spectrum.
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Abstract
Methods and apparatus for estimating and removing spectral interference improve precision and robustness of non-invasive analyte measurement using Near-Infrared (NIR) spectroscopy. The estimation of spectral interference is accomplished, either, through multivariate modeling or discrete factor analysis, using a calibration set of samples in which the interference is orthogonal to the analyte signal of interest, or where the shape of the interference is known. Each of the methods results in a multivariate model in which the spectral interference is estimated for a new sample and removed by vector subtraction. Independent models based on classes of sample variability are used to collapse spectral interference and determine more accurately which model is best equipped to estimate the signal of interference in the new sample. Principal components analysis and other commonly known analytical techniques can be used to determine class membership.
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Citations
67 Claims
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1. An apparatus for modeling and removing targeted interfering signals from spectral measurements comprising:
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means for measuring a spectrum of a sample; and
at least one interference model, wherein said interference is approximately orthogonal to an analyte signal of interest, said interference model adapted to remove spectral interference from said measured spectrum. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for estimating and removing spectral interference from a measured spectrum comprising the steps of:
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providing one or more calibration sets of exemplary spectral measurements and corresponding measured property values;
providing one or more spectral measurements, each of said measurements comprising a sample;
calculating one or more interference models from said one or more calibration sets, wherein said interference is approximately orthogonal to an analyte signal of interest;
estimating said interference; and
removing said interference from said sample. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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Specification