Membrane for use with implantable devices
First Claim
1. A biointerface membrane for use with an implantable device comprising;
- a) a first domain distal to said implantable device wherein said first domain supports tissue ingrowth and interferes with barrier-cell layer formation and b) a second domain proximal to said implantable device wherein said second domain is resistant to cellular attachment and is impermeable to cells and cell processes.
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Abstract
The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
1165 Citations
43 Claims
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1. A biointerface membrane for use with an implantable device comprising;
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a) a first domain distal to said implantable device wherein said first domain supports tissue ingrowth and interferes with barrier-cell layer formation and b) a second domain proximal to said implantable device wherein said second domain is resistant to cellular attachment and is impermeable to cells and cell processes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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29. A biointerface membrane comprising the properties of:
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a) promoting tissue ingrowth into;
b) interfering with barrier cell formation on or within;
c) resisting barrier cell attachment to; and
d) blocking cell penetration into said membrane.
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30. A biointerface membrane comprising at least two domains in combination that are adapted to:
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a) permit tissue ingrowth into said membrane;
b) interfere with barrier cell formation on or within said membrane;
c) resist barrier cell attachment to said membrane; and
d) block cell penetration into said membrane.
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Specification