Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore

• US 20030024250A1
• Filed: 08/01/2002
• Published: 02/06/2003
• Est. Priority Date: 05/15/2001
• Status: Active Grant

• Current Assignee: Cryopen, Inc.
• Original Assignee: Cimex Biotech Lc
• Inventors: Haas, Michael, Bailey, Richard, Krentel, Jerome F.
• Granted Patent: US 6,629,417 B2
• Time in Patent Office: Days
• US Class Current: 62/3.2
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2018/025 by circulating liquid
• CPC Class Codes: F25B 21/02 using Peltier effect; using Nernst-Ettinghausen effect
• CPC Class Codes: F25B 25/00 Machines, plants or systems, using a combination of modes of operation covered by two or more of the groups F25B1/00 - F25B23/00
• CPC Class Codes: F25B 9/14 characterised by the cycle used, e.g. Stirling cycle
• CPC Class Codes: F25D 19/006 Thermal coupling structure or interface

Abstract

A cryoprobe system utilizing a monolithic, insulated, hand-held thermal mass having an exposed tip for cryosurgical applications and the like, as well as a heat extraction base configured to interface with the thermal mass to quickly and efficiently reduce the heat of the thermal mass to cryogenic temperatures. The heat extraction base of the preferred embodiment of the present invention is configured to interface with the tip of the thermal mass, such that the tip plugs in securely to the base, to permit an efficient thermal transfer of heat from the thermal mass through the base via a heat exchange system communicating with the base which employs a low temperature cryo-refrigeration unit. The cryo-refrigeration unit may comprise a single low temperature cooling unit to reduce the temperature of the base to around minus one hundred degrees Centigrade utilizing off-the-shelf cryogenic refrigeration methods, or may utilize a series of more conventional refrigeration units in a primary and secondary heat extraction arrangement, which method may further utilize thermocouple or Peltier effect device assist to further reduce the temperature of the heat extraction base to the required temperature. Also claimed is the method of cryosurgery employing the device(s) of the present invention, and a heat pipe appliance to engage a remote treatment area.

Claims

1. A cryogenic apparatus, comprising:

an applicator, comprising;

a thermal mass having first and second ends, said thermal mass at least partially insulated so as to be held by a user;

a thermal cooling unit, comprising;

a charging station having a socket configured to removably engage said thermal mass of said applicator;

a quantity of thermally conductive fluid situated in said socket; and

cooling means for cooling said socket;

said applicator formed to engage said socket of said charging station in conjunction with said thermally conductive fluid situated in said socket so as to allow said cooling means to remove heat from said thermal mass to cryogenically cool same, said applicator further being separable from said socket, such that said chilled thermal mass may be utilized to extract heat from an application area.

2. The cryogenic apparatus of claim 1, wherein said charging station further comprises a cold plate.

3. The cryogenic apparatus of claim 2, wherein said cooling means comprises first and second, cascaded Rankine cycle refrigeration units to cool said cold plate.

4. The cryogenic apparatus of claim 3, wherein said cooling means further comprises a thermoelectric device having a hot side and a cold side, said hot side communicating with said cold plate, said cold side communicating with said socket.

5. The cryogenic apparatus of claim 1, wherein said charging station comprises a cold plate communicating with said socket, and wherein said cooling means comprises a Stirling cycle cooler having a hot end and a cold end, said cold end engaging communicating with said cold plate.

6. The cryogenic apparatus of claim 1, wherein there is further provided an application tip formed to removably engage said chilled thermal mass, said application tip configured to engage an application area to draw heat therefrom.

7. The cryogenic apparatus of claim 6, wherein said application tip comprises a heat pipe having first and second ends, said first end of said heat pipe configured to engage said chilled thermal mass, said second end of said heat pipe configured to engage a treatment area on a patient.

8. The cryogenic apparatus of claim 7, wherein heat pipe has a length, and wherein a portion of said length of said heat pipe is insulated.

9. The cryogenic apparatus of claim 8, wherein there is provided an applicator tip configured to removeably engage said second end of said heat pipe, said applicator tip configured to engage treatment area on a patient.

10. The cryogenic apparatus of claim 5, wherein there is further provided an application tip formed to removably engage said chilled thermal mass, said application tip configured to engage an application area to draw heat therefrom.

11. The cryogenic apparatus of claim 1, wherein said applicator further includes temperature indicator means for indicating the temperature of said thermal mass.

12. The cryogenic apparatus of claim 1, wherein said thermal mass contains phase change material.

13. The cryogenic apparatus of claim 2, wherein said thermally conductive fluid comprises antifreeze fluid, and wherein there is further provided an antifreeze dispenser for dispensing said antifreeze fluid into said socket, so as to maintain a predetermined level of antifreeze fluid in said socket.

14. The cryogenic apparatus of claim 13, wherein said antifreeze fluid comprises ethanol.

15. The cryogenic apparatus of claim 14, wherein said thermal mass comprises a rod of copper.

16. The cryogenic apparatus of claim 1, wherein there is further provided a heat pipe having first and second ends, said first end of said heat pipe affixed to said second end of said thermal mass, said second end of said heat pipe configured to extract heat from a treatment area.

17. A method of cryogenically cooling a treatment area, comprising the steps of:

a) providing a cryogenic apparatus, comprising;

an applicator, comprising;

a thermal mass having first and second ends, said thermal mass at least partially insulated to form a probe which may be held by a user;

a thermal cooling unit, comprising;

a charging station having a socket configured to removably engage said thermal mass of said applicator; and

cooling means for cooling said socket;

said applicator formed to engage said socket of said charging station so as to allow said cooling means to remove heat from said thermal mass so as to cryogenically cool same, said applicator further being separable from said socket, such that said chilled thermal mass may be utilized to extract heat from an application area;

b. placing a quantity of thermally conductive fluid in said socket of said charging station, and engaging said applicator to said charging station such that said socket engages said thermal mass of said applicator utilizing said thermally conductive fluid;

c. allowing said cooling means to remove heat from said thermal mass via said socket;

d. removing said applicator from said charging station;

e. utilizing said thermal mass to cool the treatment area;

f. removing said thermal mass from the treatment area.

18. A method of cryosurgically treating selected tissue on a patient, comprising the steps of:

a) providing a cryogenic apparatus, comprising;

an applicator, comprising;

a thermal mass having first and second ends, said thermal mass at least partially insulated to form a probe which may be held by a user, said first end of said thermal mass having an application tip;

a tip cover configured to removeably engage said application tip, said tip cover formed of a thermally conductive material;

a thermal cooling unit, comprising;

a charging station having a socket configured to removably engage said thermal mass of said applicator; and

cooling means for cooling said socket;

said applicator formed to engage said socket of said charging station so as to allow said cooling means to remove heat from said thermal mass so as to cryogenically cool same, said applicator further being separable from said socket, such that said chilled thermal mass may be utilized to extract heat from an application area;

b. engaging said applicator to said charging station such that said socket engages said thermal mass of said applicator;

c. allowing said cooling means to remove heat from said thermal mass via said socket;

d. applying said tip cover to interface with said application tip of said thermal mass;

e. placing said application tip having said tip cover thereon in the vicinity of the selected tissue, and utilizing said thermal mass to freeze the selected tissue, via said tip cover;

f. removing said thermal mass from the vicinity of the selected tissue, while allowing said tip cover to remain in the vicinity of the selected tissue, providing a removed tip cover;

g. allowing said removed tip cover to warm due to contact with ambient air and the selected tissue; and

h. removing said removed tip cover from said selected tissue.

19. The method of claim 18, wherein step “

d”

further includes the step of providing a quantity of thermal conductive fluid between said application tip and said tip cover, so as to form a liquid thermal interface between said application tip and said tip cover.

20. The method of claim 19, wherein in step “

f”

said tip cover is frozen to the selected tissue so as to adhere to said tissue, and wherein in step “

g”

said removed tip cover is allowed to thaw so as to no longer adhere to said tissue.

21. The method of claim 18, wherein step “

C”

further includes the step of engaging the first end of a heat pipe to said thermal mass, and wherein the tip cover of step “

D”

is applied to the second end of said heat pipe, so as to allow said heat pipe to transfer heat from said tip cover to said thermal mass.

22. A method of Cryosurgery, comprising the steps of:

a. providing a thermal mass having an applicator tip;

b. placing said applicator tip into a liquid bath of chilled thermally conductive fluid so as to chill said applicator tip and said thermal mass, removing said applicator tip from said liquid bath, providing a chilled applicator tip having a layer of thermally conductive fluid thereupon;

c. extracting heat from a treatment area utilizing said chilled applicator tip;

d. allowing said chilled thermal mass to extract heat from said treatment area so as to freeze and ablate said treatment area, providing a frozen treatment area;

while

e. allowing said layer of thermally conductive fluid on said applicator tip to prevent said frozen treatment area from adhering from said applicator tip when said applicator tip is removed from said frozen treatment area.

23. A cryogenic treatment system, comprising:

a first Rankine cycle refrigerator unit providing chilled refrigerant;

a second Rankine cycle refrigerator unit cascaded with said first Rankine cycle refrigerator unit, so as to further chill said chilled refrigerant, providing cryogenically chilled refrigerant;

a cold plate formed to interface with said cryogenically chilled refrigerant, providing a cryogenically chilled cold plate;

a thermoelectric device having hot and cold sides, said hot side of said thermoelectric device formed to interface with said cold plate, providing a cryogenically chilled thermoelectric device,

a socket in communication with said cold side of said thermoelectric device, so as to provide a cryogenically chilled socket having a lower temperature than said cryogenically chilled cold plate; and

a thermal mass configured to engage said socket for cooling said thermal mass, providing a cooled thermal mass, wherein said cooled thermal mass may be removed from said socket and applied to a treatment area.

24. A cryogenic treatment system, comprising:

a thermal mass having first and second ends, said thermal mass at least partially insulated so as to be held by a user;

a thermal cooling unit, comprising;

a charging station having a socket configured to removably engage said thermal mass; and

cooling means for cooling said socket;

said thermal mass formed to engage said socket of said charging station so as to allow said cooling means to remove heat from said thermal mass to cryogenically cool same, said thermal mass further being separable from said socket; and

a heat pipe having first and second ends, said first end of said heat pipe configured to engage to said thermal mass, said second end of said heat pipe configured to extract heat from a treatment area.