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Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin

  • US 20030026798A1
  • Filed: 05/10/2002
  • Published: 02/06/2003
  • Est. Priority Date: 11/13/1999
  • Status: Active Grant
First Claim
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1. A method of administering a therapeutic dose of a reversibly inactivated acidified fibrinolytic composition to a human or animal having a thrombotic occlusion, comprising the steps of:

  • a) identifying a human or animal having a thrombotic occlusion; and

    b) administering parenterally to the human or animal a therapeutic dose of a pharmaceutically acceptable reversibly inactivated acidified fibrinolytic composition substantially free of plasminogen activator, wherein the therapeutic dose is delivered into or proximally to the thrombotic occlusion.

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