Guided mode resonant filter biosensor using a linear grating surface structure
First Claim
Patent Images
1. A biosensor comprising:
- (a) a one-dimensional grating layer comprised of a material having a high refractive index;
(b) a low refractive index material layer that supports the one-dimensional grating layer; and
(c) one or more specific binding substances immobilized on the surface of the one-dimensional grating layer opposite of the low refractive index material layer;
wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect.
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
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Citations
54 Claims
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1. A biosensor comprising:
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(a) a one-dimensional grating layer comprised of a material having a high refractive index;
(b) a low refractive index material layer that supports the one-dimensional grating layer; and
(c) one or more specific binding substances immobilized on the surface of the one-dimensional grating layer opposite of the low refractive index material layer;
wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 33)
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25. A biosensor comprising:
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(a) a one-dimensional grating surface structure comprised of a material having a low refractive index;
(b) a high refractive index material layer that is applied on top of the low refractive index one-dimensional grating layer; and
(c) one or more specific binding substances immobilized on a surface of the high refractive index layer opposite of the one-dimensional grating surface structure comprised of a material having a low refractive index;
wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A biosensor comprising:
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(a) a one-dimensional or two-dimensional grating layer comprised of a material having a high refractive index;
(b) a low refractive index material layer that supports the one-dimensional or two-dimensional grating layer;
(c) a surface modification layer on a surface of the one-dimensional or two-dimensional grating layer opposite of the low refractive index material layer; and
(d) one or more specific binding substances immobilized on a surface of the surface modification layer opposite of the one-dimensional or two-dimensional grating layer;
wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum. - View Dependent Claims (50, 51, 53, 54)
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52. A biosensor comprising:
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(a) a grating layer comprising a one-dimensional or two-dimensional grating on a first surface;
(b) a interfacial layer on the first surface of the grating layer;
(c) a high refractive index material layer on the surface of the interfacial layer opposite of the grating layer; and
(d) one or more specific binding substances immobilized on a surface of the high refractive index material layer opposite of the interfacial layer;
wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum.
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Specification