Device for the analysis of chemical or biochemical specimens, comparative analysis, and associated analysis process
First Claim
1. Device for the chemical or biochemical analysis of biological or chemical samples, notably for a comparative analysis of at least two samples, comprising multiple fractionation micro-columns (2) for the fractionation of sample components, each fractionation micro-column (2) comprising at least a micro-channel segment fitted with intermediate separation means, the microchannel segment comprising an inlet for the introduction of a sample-enriched mobile phase and an outlet for the evacuation of the fluids and situated at a teminal extremity, characterized by the fact that it comprises capture fluidic means (7), for the capture of the fractionated products, which are situated at the level of a terminal element of each fractionation micro-columns (2) and upstream from the evacuation outlet, by capture micro-channels which are used to collect the fractionation products and by groups of selective micro-cantilevers (13) which are associated with the fractionation micro-columns (2), are situated downstream from the capture micro-channels, a micro-cantilever (13) being fitted with detection means which are associated with analytical means.
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Abstract
A device for the chemical or biochemical analysis of biological or chemical samples, notably for a comparative analysis of at least two samples, comprises multiple fractionation micro-columns 2 for the fractionation of sample components, each fractionation micro-column 2 comprising at least a micro-channel 3 segment fitted with intermediate separation means, the micro-channel 3 segment comprising an inlet 3a for the introduction of a sample-enriched mobile phase and an outlet 3b for the evacuation of the fluids and situated at a teminal extremity. The device comprises also capture fluidic means 7 of the fractionated products which are located at a terminal element 9 of each fractionation micro-columns 2 and upstream from the evacuation outlet 3b, capture micro-channels 8 which are used to collect the captured fractionation products and groups of selective micro-cantilevers 13 which are associated with the fractionation micro-columns 2 and situated downstream from the capture micro-channels 8, a micro-cantilever 13 being fitted with detection means which are associated with analytical means.
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Citations
25 Claims
- 1. Device for the chemical or biochemical analysis of biological or chemical samples, notably for a comparative analysis of at least two samples, comprising multiple fractionation micro-columns (2) for the fractionation of sample components, each fractionation micro-column (2) comprising at least a micro-channel segment fitted with intermediate separation means, the microchannel segment comprising an inlet for the introduction of a sample-enriched mobile phase and an outlet for the evacuation of the fluids and situated at a teminal extremity, characterized by the fact that it comprises capture fluidic means (7), for the capture of the fractionated products, which are situated at the level of a terminal element of each fractionation micro-columns (2) and upstream from the evacuation outlet, by capture micro-channels which are used to collect the fractionation products and by groups of selective micro-cantilevers (13) which are associated with the fractionation micro-columns (2), are situated downstream from the capture micro-channels, a micro-cantilever (13) being fitted with detection means which are associated with analytical means.
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16. Group of chemical or biochemical comparative analyses of at least two chemical or biological which is characterized by the fact that it comprises at least two devices for the chemical or biochemical analysis of biological or chemical samples, notably for a comparative analysis of at least two samples, these devices comprising multiple fractionation micro-columns (2) for the fractionation of sample components, each fractionation micro-column (2) comprising at least a micro-channel segment fitted with intermediate separation means, the micro-channel segment comprising an inlet for the introduction of a sample-enriched mobile phase and an outlet for the evacuation of the fluids and situated at a teminal extremity, characterized by the fact that it comprises capture fluidic means (7), for the capture of the fractionated products, which are situated at the level of a terminal element of each fractionation micro-columns (2) and upstream from the evacuation outlet, by capture micro-channels which are used to collect the fractionation products and by groups of selective micro-cantilevers (13) which are associated with the fractionation micro-columns (2), are situated downstream from the capture micro-channels, a micro-cantilever (13) being fitted with detection means which are associated with analytical means.
- 17. Process for the chemical or biochemical analysis of chemical or biological samples characterized by the fact that the differential fractionation of a sample enriched mobile phase is performed, that different fractionation products are simultaneously captured and that each fractionation products is analyzed by a selective micro-cantilever group.
Specification