Compositions and delivery systems for administration of a local anesthetic agent
First Claim
1. A pharmaceutical composition comprising (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, an effective penetration enhancing amount of a penetration enhancer, and a polymer selected from the group consisting of hydrophilic polymers, hydrophobic polymers and combinations thereof, wherein local anesthetic activity is provided within about thirty minutes of application of the composition to a patient'"'"'s body surface.
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Accused Products
Abstract
A pharmaceutical composition is provided for topical administration of a local anesthetic agent. The composition comprises (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, a penetration enhancer, and polymer, which may be a hydrophilic polymer, a hydrophobic polymer or a combination thereof. The composition can be in the form of a gel, or it may form a film following application to a patient'"'"'s body surface and evaporation of the monohydric alcohol. The composition provides rapid onset of local anesthesia as well as penetration of the active agent into the skin. Methods and drug delivery systems for administration of local anesthetic agents are also provided.
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Citations
56 Claims
- 1. A pharmaceutical composition comprising (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, an effective penetration enhancing amount of a penetration enhancer, and a polymer selected from the group consisting of hydrophilic polymers, hydrophobic polymers and combinations thereof, wherein local anesthetic activity is provided within about thirty minutes of application of the composition to a patient'"'"'s body surface.
- 46. A method for administering a local anesthetic agent to a patient comprising topically administering to the patient'"'"'s body surface a composition comprising (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, a penetration enhancer, and a polymer selected from the group consisting of hydrophilic polymers, hydrophobic polymers and combinations thereof, wherein local anesthetic activity is provided within about thirty minutes following topical administration.
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50. A drug delivery system for topical administration of a local anesthetic agent, wherein the system is in the form of a laminated composite comprising:
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(a) a drug reservoir layer containing a pharmaceutical composition of (i) a therapeutically effective amount of a local anesthetic agent, (ii) a monohydric alcohol, and (iii) an effective enhancing amount of a penetration enhancer; and
(b) a backing layer laminated to the drug reservoir layer that serves as the outer surface of the system following application to a patient'"'"'s body surface. - View Dependent Claims (51, 52, 53, 54, 55, 56)
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Specification