Polymer compositions containing bioactive agents and methods for their use
First Claim
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1. An implantable medical device having at least one polymer coating composition, the polymer coating prepared from a reaction mixture of:
- (a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the mixture;
(b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
(c) a bioactive agent; and
optionally;
(d) a chain extender.
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Abstract
Embodiments of the invention provide polymer coated implantable medical devices having a bioactive material posited in or on at least a portion of the coating layer, wherein the coating layer provides for the controlled release of the bioactive material from the coating layer. Preferably, the medical device is an intravascular stent.
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Citations
21 Claims
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1. An implantable medical device having at least one polymer coating composition, the polymer coating prepared from a reaction mixture of:
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(a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the mixture;
(b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
(c) a bioactive agent; and
optionally;
(d) a chain extender. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A polymer composition, the polymer composition formed by admixing (a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the admixture;
- (b) a hydrophilic polymer selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
(c) a bioactive agent and, optionally, (d) a chain extender.
- (b) a hydrophilic polymer selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
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20. A method for making a polymer composition, the method comprising:
- admixing (a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the admixture;
(b) a hydrophilic polymer selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
(c) a bioactive agent and, optionally, (d) a chain extender, thereby forming the polymer composition.
- admixing (a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the admixture;
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21. An implantable medical device having at least one polymer coating composition, the polymer coating prepared from a reaction mixture of:
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(a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the mixture;
(b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
(d) glucose oxidase;
(c) a bioactive agent wherein the bioactive agent is capable of being released from the polymer coating into the environment in which the medical device is placed, and wherein the bioactive agent is an anti-thrombocytic, anti-inflammatory or anti-proliferative agent;
wherein the release of the bioactive agent is modulated by a product that is produced from a reaction between the glucose oxidase that is present in the polymer coating and glucose that is present environment in which the medical device is placed.
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Specification