Evaluating neuropshychiatric diseases using a specimen-linked database
First Claim
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1. An information system comprising:
- a specimen-linked database comprising a plurality of information about a tissue microarray wherein the tissue microarray is identified by an identifier, the tissue microarray comprising a plurality of samples from at least one patient with a neuropsychiatric disorder;
at least one user device connectable to a network wherein the user device displays an interface wherein the plurality of information can be inputted into the interface; and
an information management system for searching the specimen-linked database and determining relationships between the plurality of information.
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Abstract
The invention relates to a method and system for identifying and evaluating the responses of a patient to a neuropsychiatric disorder. Preferably, both physiological and behavioral responses are linked to molecular profiling data, i.e., data relating to the expression of a plurality of genes in tissues from the patient with these diseases. In one aspect, the invention provides a tissue information system comprising a specimen-linked database and an information management system for accessing, organizing, and displaying tissue information obtained from tissue microarrays comprising samples from patients with neuropsychiatric disorders.
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Citations
75 Claims
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1. An information system comprising:
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a specimen-linked database comprising a plurality of information about a tissue microarray wherein the tissue microarray is identified by an identifier, the tissue microarray comprising a plurality of samples from at least one patient with a neuropsychiatric disorder;
at least one user device connectable to a network wherein the user device displays an interface wherein the plurality of information can be inputted into the interface; and
an information management system for searching the specimen-linked database and determining relationships between the plurality of information. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An information system comprising:
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a tissue microarray having a plurality of samples wherein the plurality of samples are from at least one patient with a neuropsychiatric disorder;
a specimen-linked database comprising information about the tissue microarray wherein the tissue microarray is identified by an identifier;
at least one user device connectable to a network, for displaying an interface wherein a plurality if information can be inputted into the interface; and
an information management system for searching the specimen-linked database and determining relationships between the plurality of information. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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54. A method for obtaining information relating to physiological responses of a patient suspected of having a neuropsychiatric disorder comprising:
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creating a tissue microarray wherein the tissue microarray includes a plurality of sublocations and a plurality of samples wherein each sublocation includes a sample;
identifying the tissue microarray with an identifier and identifying each sublocation with a set of coordinates;
treating each of the plurality of samples with a molecular probe;
entering a plurality of information relating to each sample into a specimen-linked database; and
correlating the identifier of the tissue microarray and the coordinates of the sublocation with the plurality of information using an information management system. - View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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65. A method for obtaining information about a sample in a tissue microarray comprising:
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creating the tissue microarray comprising a plurality of samples wherein at least one of the samples being from a patient with a neuropsychiatric disorder;
treating each of the plurality of samples with a molecular probe;
entering a plurality of information relating to each sample into a specimen-linked database;
correlating the identifier of the tissue microarray and the coordinates of a sublocation with the plurality of information using an information management system; and
searching the specimen-linked database with the information management system and displaying a plurality of search results on an interface of a user device. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
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Specification