Cell maintenance and proliferation
First Claim
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1. A method of regulating the differentiation potential of a pluripotent or pluripotent-related cell which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule in a pluripotent or pluripotent-related cell.
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Abstract
A method of regulating the differentiation potential of a pluripotent or pluripotent-related cell which method Includes manipulating the expression and/or activity of a cell differentiation regulatory molecule in a pluripotent or pluripotent related cell.
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27 Claims
- 1. A method of regulating the differentiation potential of a pluripotent or pluripotent-related cell which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule in a pluripotent or pluripotent-related cell.
- 14. A method of regulating the differentiation potential of a pluripotent or pluripotent-related cell, which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule selected from the group consisting of STAT3, a downstream biochemical target of STAT3 and a molecule displaying similar activities in a pluripotent or pluripotent-related cell.
- 17. A method of regulating the differentiation potential of a pluripotent or pluripotent-related cell, which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule selected from the group consisting of a member of the myc family, an upstream regulator of a member of the myc family and a molecule displaying similar activities in a pluripotent or pluripotent-related cell.
- 19. A method for the maintenance and the proliferation of human pluripotent or pluripotent-related cells, which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule selected from one or more of the group consisting of a downstream biochemical target of LIF, an oncogene or oncoprotein, an upstream regulator of an oncogene or oncoprotein, and a molecule displaying similar activities, in a human pluripotent or pluripotent-related cell.
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21. A method for the maintenance and proliferation of human pluripotent or pluripotent-related cells, which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule selected from one or more of the group consisting of STAT3, a downstream biochemical target of STAT3 and a molecule displaying similar activities, in a human pluripotent or pluripotent-related cells.
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22. A method for the maintenance and proliferation of human pluripotent or pluripotent-related cells, which method includes manipulating the expression and/or activity of a cell differentiation regulatory molecule selected from one or more of the group consisting of a member of the myc family, an upstream regulator of a member of the myc family and a molecule displaying similar activities, in a human pluripotent or pluripotent-related cell.
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