Composition and methods for the treatment of skin disorders
First Claim
Patent Images
1. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
- administering to said subject a therapeutically effective amount of an agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof.
1 Assignment
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Accused Products
Abstract
Methods and pharmaceutical compositions for use in the treatment of a benign and/or a malignant proliferative pathologies are disclosed. The methods comprise administration of nicotinamide or its analogs and/or cADPR or its analogs, optionally in combination with a vitamin D3 analog or a Vitamin A analog.
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Citations
176 Claims
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1. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of an agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of an agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with a second agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with a therapeutically effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
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37. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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45. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, in combination with a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52)
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53. A method of treating a benign or malignant hyperproliferative epidermal pathology in a subject in need thereof, the method comprising:
administering to said subject a therapeutically effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, in combination with a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60)
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61. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of an agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamnide metabolite and prodrugs thereof. - View Dependent Claims (62)
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63. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of an agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof.
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64. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of a first agent selected from the group consisting of nicotinamnide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with am effective amount of a second agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof.
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65. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with an effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof.
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66. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of an agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with an effective amount of an agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof.
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67. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, in combination with an effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof.
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68. A method of increasing anti-oxidative properties of epidermal cells, the method comprising:
contacting said cells with an effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof in combination with an effective amount of a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof.
- 69. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as an active ingredient, a therapeutically effective amount of an agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
- 89. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as an active ingredient, a therapeutically effective amount of an agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
- 106. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as a combination of active ingredients, a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, a therapeutically effective amount of a second agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
- 117. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as a combination of active ingredients, a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, a therapeutically effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
- 129. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as a combination of active ingredients, a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, a therapeutically effective amount of a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonists a Vitamin A derivative and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
- 141. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as a combination of active ingredients, a therapeutically effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, a therapeutically effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
- 152. A pharmaceutical, cosmetic or cosmeceutical composition, identified for use in the treatment of benign or malignant hyperproliferative epidermal pathology, comprising, as a combination of active ingredients, a therapeutically effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, a therapeutically effective amount of a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof, and a pharmaceutically, cosmetically or cosmeceutically acceptable carrier.
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163. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising:
contacting said cells with a therapeutically effective amount of all agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof.
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164. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising:
contacting said cells with a therapeutically effective amount of an agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof.
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165. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising:
contacting said cells with a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with a therapeutically effective amount of a second agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof.
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166. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising:
contacting said cells with a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with a therapeutically effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof.
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167. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising:
contacting said cells with a therapeutically effective amount of a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, in combination with a therapeutically effective amount of a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof.
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168. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising:
contacting said cells with a therapeutically effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, in combination with a therapeutically effective amount of a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof.
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169. A method of inhibiting proliferation of benign or malignant hyperproliferative epidermal cells, the method comprising;
contacting said cells with a therapeutically effective amount of a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, in combination with a therapeutically effective amount of a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof.
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170. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as an active ingredient an agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof.
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171. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, as an active ingredient an agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof.
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172. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, and a second agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, said first agent and said second agent are individually packaged within the pharmaceutical, cosmetic or cosmeceutical kit.
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173. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, and a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof, said first agent and said second agent are individually packaged within the pharmaceutical, cosmetic or cosmeceutical kit.
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174. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, a first agent selected from the group consisting of nicotinamide, a nicotinamide agonist, a nicotinamide derivative, a nicotinamide metabolite and prodrugs thereof, and a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof, said first agent and said second agent are individually packaged within the pharmaceutical, cosmetic or cosmeceutical kit.
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175. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, and/or for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous, comprising, a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, and a second agent selected from the group consisting of Vitamin D3, a Vitamin D3 metabolite, a Vitamin D3 agonist, a Vitamin D3 derivative and prodrugs thereof, said first agent and said second agent are individually packaged within the pharmaceutical, cosmetic or cosmeceutical kit.
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176. A pharmaceutical, cosmetic or cosmeceutical kit, identified in print for use in the treatment of a benign or malignant hyperproliferative epidermal pathology, for use in the treatment of a condition whereby increasing anti-oxidative properties of epidermal cells is advantageous and/or for use in anti-cancer protection, comprising, a first agent selected from the group consisting of cyclic adenosine diphosphate-ribose (cADPR), a cADPR derivative, a cADPR metabolite, a cADPR agonist and prodrugs thereof, and a second agent selected from the group consisting of Vitamin A, a Vitamin A metabolite, a Vitamin A agonist, a Vitamin A derivative and prodrugs thereof, said first agent and said second agent are individually packaged within the pharmaceutical, cosmetic or cosmeceutical kit.
Specification