Manufacture of thyroid hormone tablets having consistent active moiety amounts
First Claim
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1. an apparatus for transporting thyroid hormone drug formulations from a blender to a tableting machine comprising:
- a blender discharge section;
a portable container section;
a portable container discharge section;
and a conical tablet press inlet section;
wherein mass flow of the drug formulation is maintained in all sections of the apparatus.
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Abstract
An apparatus for the transport of thyroid hormone drug formulations from a blender to a tablet press using mass flow of the formulation in order to maintain consistent tablet compositions during manufacture of the tablets.
101 Citations
8 Claims
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1. an apparatus for transporting thyroid hormone drug formulations from a blender to a tableting machine comprising:
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a blender discharge section;
a portable container section;
a portable container discharge section;
and a conical tablet press inlet section;
wherein mass flow of the drug formulation is maintained in all sections of the apparatus.
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2. The apparatus of claim [c1], [Claim Reference]
wherein the portable container discharge section comprises a vent cone section.
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3. The apparatus of claim [c1], [Claim Reference] wherein the portable container discharge section comprises a vent cone section and a Y-branch section.
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4. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises one or more active moieties selected from the group consisting of levothyroxine sodium and liothyronine sodium.
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5. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety liothyronine sodium, calcium sulfate, gelatin, starch, stearic acid, sucrose and talc.
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6. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety levothyroxine sodium, lactose, microcrystalline cellulose, pregelatinized starch, and magnesium stearate.
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7. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety levothyroxine sodium and inert ingredients suitable for treating canine hypothyroidism.
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8. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety levothyroxine sodium and inert ingredients suitable for treating feline hypothyroidism.
Specification