Manufacture of thyroid hormone tablets having consistent active moiety amounts

• US 20030032675A1
• Filed: 02/15/2002
• Published: 02/13/2003
• Est. Priority Date: 02/15/2001
• Status: Abandoned Application

• Current Assignee: Elaine A. Strauss, Floyd Meredith, Franz G. Andrew, Matthew Smith, Philip A. Dimenna, Rocco L. Gemma, Scott C. Vaaler
• Original Assignee: Elaine A. Strauss, Floyd Meredith, Franz G. Andrew, Matthew Smith, Philip A. Dimenna, Rocco L. Gemma, Scott C. Vaaler
• Inventors: Smith, Matthew, Meredith, Floyd, Vaaler, Scott C., Gemma, Rocco L., Franz, G. Andrew, Strauss, Elaine A., DiMenna, Philip A.
• Application Number:
  US10/076,731
• Publication Number:
  US 20030032675A1
• Time in Patent Office: Days
• US Class Current: 514/567
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: B01F 23/60 Mixing solids with solids
• CPC Class Codes: B01F 25/433 Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• CPC Class Codes: B01F 25/4334 Mixers with a converging cross-section
• CPC Class Codes: B01F 25/82 uniting flows of material taken from different parts of a receptacle or from a set of different receptacles

Abstract

An apparatus for the transport of thyroid hormone drug formulations from a blender to a tablet press using mass flow of the formulation in order to maintain consistent tablet compositions during manufacture of the tablets.

Claims

1. an apparatus for transporting thyroid hormone drug formulations from a blender to a tableting machine comprising:

a blender discharge section;

a portable container section;

a portable container discharge section;

and a conical tablet press inlet section;

wherein mass flow of the drug formulation is maintained in all sections of the apparatus.

2. The apparatus of claim [c1], [Claim Reference]

wherein the portable container discharge section comprises a vent cone section.

3. The apparatus of claim [c1], [Claim Reference] wherein the portable container discharge section comprises a vent cone section and a Y-branch section.

4. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises one or more active moieties selected from the group consisting of levothyroxine sodium and liothyronine sodium.

5. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety liothyronine sodium, calcium sulfate, gelatin, starch, stearic acid, sucrose and talc.

6. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety levothyroxine sodium, lactose, microcrystalline cellulose, pregelatinized starch, and magnesium stearate.

7. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety levothyroxine sodium and inert ingredients suitable for treating canine hypothyroidism.

8. The apparatus of claim [c1], [Claim Reference] wherein the thyroid drug formulation comprises the active moiety levothyroxine sodium and inert ingredients suitable for treating feline hypothyroidism.