Methods and devices for delivery of therapeutic capable agents with variable release profile
First Claim
Patent Images
1. A device for intracorporeal use within a patient'"'"'s body, the device comprising:
- a structure having a longitudinal dimension defined by proximal and distal end portions and an intermediate portion disposed therebetween; and
at least one source of at least one therapeutic capable agent associated with the structure and configured to release the therapeutic capable agent at a longitudinally variable release profile along the structure longitudinal dimension.
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Abstract
The present invention provides improved stents and other prostheses for delivering substances to vascular and other luminal and intracorporeal environments. In particular, the present invention provides for therapeutic capable agent stents with a variable release profile along a length of the stent.
290 Citations
45 Claims
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1. A device for intracorporeal use within a patient'"'"'s body, the device comprising:
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a structure having a longitudinal dimension defined by proximal and distal end portions and an intermediate portion disposed therebetween; and
at least one source of at least one therapeutic capable agent associated with the structure and configured to release the therapeutic capable agent at a longitudinally variable release profile along the structure longitudinal dimension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 41)
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23. A device for intracorporeal use within a patient'"'"'s body, the device comprising:
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a radially expansible implantable structure having a longitudinal dimension defined by proximal and distal end portions and an intermediate portion disposed therebetween, the structure having a plurality of regions along its longitudinal dimension exhibiting different mechanical profiles during expansion of the structure and including relatively lower and relatively higher mechanical profiles; and
at least one source of at least one therapeutic capable agent associated with the relatively higher mechanical profile regions at the structure end portions and with the relatively lower mechanical profile regions at the structure intermediate portion. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A device for intracorporeal use within a patient'"'"'s body, the device comprising:
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a structure; and
at least one source of at least one therapeutic capable agent associated with the structure and being configured to provide the therapeutic capable agent at an amount effective to inhibit neointimal hyperplasia at an area longitudinally adjacent the structure. - View Dependent Claims (31, 32, 33, 34, 35, 36)
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37. A device for intracorporeal use within a patient'"'"'s body, the device comprising:
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an implantable structure having proximal and distal portions and an intermediate portion disposed therebetween;
at least one source of at least one therapeutic capable agent associated with the structure and configured to release the therapeutic capable agent within the patient'"'"'s body at a release profile being greater at the end portions than at the intermediate portion. - View Dependent Claims (38, 39, 40)
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42. A method for treatment of a patient, the method comprising:
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providing a vascular prosthesis comprising a structure having a longitudinal dimension defined by proximal and distal end portions and an intermediate portion therebetween and at least one source of at least one therapeutic capable agent associated with the structure;
implanting the vascular prosthesis within the patient'"'"'s vasculature including a susceptible tissue site; and
releasing the therapeutic capable agent at a longitudinally variable release profile along the structure longitudinal dimension.
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43. A method for treatment of a patient, the method comprising:
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providing a vascular prosthesis comprising a structure having a longitudinal dimension defined by proximal and distal end portions and an intermediate portion therebetween, the structure having a plurality of regions exhibiting relatively lower and relatively higher mechanical profiles, and at least one source of at least one therapeutic capable agent associated with the relatively higher mechanical profile regions at the structure end portions and with the relatively lower mechanical profile regions at the structure intermediate portion;
implanting the vascular prosthesis within the patient'"'"'s vasculature including a susceptible tissue site; and
releasing the therapeutic capable agent.
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44. A method for treatment of a patient, the method comprising:
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providing a vascular prosthesis comprising a structure and at least one source of at least one therapeutic capable agent associated with the structure;
implanting the vascular prosthesis within the patient'"'"'s vasculature including a susceptible tissue site; and
releasing the therapeutic capable agent at an amount effective to inhibit neointimal hyperplasia at an area longitudinally adjacent the structure.
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45. A method for treatment of a patient, the method comprising:
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providing a vascular prosthesis comprising a structure having a longitudinal dimension defined by proximal and distal end portions and an intermediate portion therebetween and at least one source of at least one therapeutic capable agent associated with the structure;
implanting the vascular prosthesis within the patient'"'"'s vasculature including a susceptible tissue site; and
releasing the therapeutic capable agent at a release profile being greater at the end portions than at the intermediate portion.
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Specification