Automated hypothesis testing
First Claim
1. A method for automated hypothesis testing, said method comprising the steps of:
- a. generating or selecting a plurality of computer simulation models of a biological or physiological system;
b. calibrating said plurality of models;
c. comparing or ranking said plurality of models based upon the goodness of fit of each model to experimental data; and
d. designing at least one experiment to help differentiate between two or more statistically equivalent models.
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Abstract
The present invention relates to a method and system for automatically constructing computer simulation models of biological systems. More specifically, a series of simulation models are created, or selected from a repository of standard models, preferably based on experimental data. These models are then calibrated, if necessary, based upon experimental data and then compared to each other for goodness of fit to a set of experimental data; the best models can then be selected based upon the goodness-of-fit calculations. Another aspect of the invention provides for automated design of additional experiments to differentiate between models that have the same or similar goodness-of-fit scores.
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Citations
54 Claims
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1. A method for automated hypothesis testing, said method comprising the steps of:
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a. generating or selecting a plurality of computer simulation models of a biological or physiological system;
b. calibrating said plurality of models;
c. comparing or ranking said plurality of models based upon the goodness of fit of each model to experimental data; and
d. designing at least one experiment to help differentiate between two or more statistically equivalent models. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for automated hypothesis testing, said system comprising the steps of:
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a. a hypothesis generation system for generating or selecting a plurality of computer simulation models of a biological or physiological system;
b. a parameter estimation system for calibrating said plurality of models;
c. a model scoring system for comparing or ranking said plurality of models based upon the goodness of fit of each model to experimental data; and
d. an experimental design system for designing at least one experiment to help differentiate between two or more statistically equivalent models. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for automated hypothesis testing, said method comprising the steps of:
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a. generating or selecting a plurality of computer simulation models of a biological or physiological system;
b. calibrating said plurality of models; and
c. comparing or ranking said plurality of models based upon the goodness of fit of each model to experimental data. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A system for automated hypothesis testing, said system comprising the steps of:
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a. a hypothesis generation system for generating or selecting a plurality of computer simulation models of a biological or physiological system;
b. a parameter estimation system for calibrating said plurality of models; and
c. a model scoring system for comparing or ranking said plurality of models based upon the goodness of fit of each model to experimental data. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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Specification