Systems and methods for treatment of coronary artery disease
First Claim
1. A method for treating coronary artery disease, comprising:
- providing a stimulator that generates a pulse in accordance with prescribed parameters;
providing a catheter connected to the stimulator, which catheter includes a discharge portion;
implanting the catheter discharge portion near at least one cardiac tissue to be stimulated;
implanting the stimulator at a location remote from the at least one tissue to be stimulated;
tunneling the catheter subcutaneously to the stimulator location; and
delivering via the stimulator and catheter infusion pulses of at least one drug as at least one treatment for coronary artery disease to the at least one cardiac tissue, which tissue comprises at least one of a coronary artery, a branch of a coronary artery, a coronary vein, a branch of a coronary vein, the aorta, the left ventricle, the right ventricle, the left atrium, the right atrium, a pulmonary vein, the coronary sinus, the inferior vena cava, the superior vena cava, the sino-atrial (SA) node, and the atrioventricular (AV) node.
3 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems for treatment of coronary artery disease (CAD) include implantation of the discharge portion(s) of a catheter and, optionally, electrodes on a lead, near the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, the aorta, the left ventricle, the left atrium, and/or the pulmonary veins, among other locations. Disclosed treatments include drugs used for acute treatment of CAD, for chronic treatment of CAD, to promote angiogenesis, and/or as AGE Crosslink Breakers, among other drugs. For instance, the systems and methods reduce or eliminate the incidence of CAD and related morbidities, improve symptoms resulting from CAD, and/or improve cardiac blood flow, cardiac function, and patient quality of life.
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Citations
23 Claims
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1. A method for treating coronary artery disease, comprising:
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providing a stimulator that generates a pulse in accordance with prescribed parameters;
providing a catheter connected to the stimulator, which catheter includes a discharge portion;
implanting the catheter discharge portion near at least one cardiac tissue to be stimulated;
implanting the stimulator at a location remote from the at least one tissue to be stimulated;
tunneling the catheter subcutaneously to the stimulator location; and
delivering via the stimulator and catheter infusion pulses of at least one drug as at least one treatment for coronary artery disease to the at least one cardiac tissue, which tissue comprises at least one of a coronary artery, a branch of a coronary artery, a coronary vein, a branch of a coronary vein, the aorta, the left ventricle, the right ventricle, the left atrium, the right atrium, a pulmonary vein, the coronary sinus, the inferior vena cava, the superior vena cava, the sino-atrial (SA) node, and the atrioventricular (AV) node. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for treating coronary artery disease (CAD), comprising:
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implanting a fully implantable stimulator system for generating stimulating pulses;
administering via the stimulator system stimulating pulses of at least one acute CAD drug;
administering via the stimulator system stimulating pulses of at least one chronic CAD drug; and
administering via the stimulator system stimulating pulses of at least one drug that reverses. CAD. - View Dependent Claims (15, 16)
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17. A system for treating coronary artery disease, comprising:
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a stimulator that generates an infusion pulse in accordance with prescribed parameters;
a catheter connected to the stimulator, which catheter includes a discharge portion;
wherein the stimulator and catheter are configured to deliver at least one drug to at least one cardiac tissue, which tissue comprises at least one of a coronary artery, a branch of a coronary artery, a coronary vein, a branch of a coronary vein, the aorta, the left ventricle, the right ventricle, the left atrium, the right atrium, a pulmonary vein, the coronary sinus, the inferior vena cava, the superior vena cava, the sino-atrial (SA) node, and the atrio-ventricular (AV) node. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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Specification