ISOLATED STROMAL CELLS FOR USE IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
First Claim
1. A method of treating a human patient having a disease, disorder or condition of the central nervous system, the method comprising obtaining a bone marrow sample from a human donor, isolating stromal cells from said bone marrow sample, and administering said isolated stromal cells to the central nervous system of said human patient, wherein the presence of said isolated stromal cells in said central nervous system effects treatment of said disease, disorder or condition.
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Accused Products
Abstract
Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and administering the isolated stromal cells to the central nervous system of the human patient, wherein the presence of the isolated stromal cells in the brain effects treatment of the disease, disorder or condition. Stromal cells which are isolated may be cultured in vitro, they may be genetically engineered to produce therapeutic compounds, and/or they may be pre-differentiated prior to administration into the central nervous system.
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Citations
20 Claims
- 1. A method of treating a human patient having a disease, disorder or condition of the central nervous system, the method comprising obtaining a bone marrow sample from a human donor, isolating stromal cells from said bone marrow sample, and administering said isolated stromal cells to the central nervous system of said human patient, wherein the presence of said isolated stromal cells in said central nervous system effects treatment of said disease, disorder or condition.
- 19. A method of directing the differentiation of an isolated stromal cell comprising culturing said isolated stromal cell in the presence of a substantially homogeneous population of differentiated cells whereby said isolated stromal cell differentiates and acquires the phenotypic characteristics of said differentiated cells.
Specification