Saliva-based methods for preventing and assessing the risk of diseases
First Claim
1. A method for predicting the risk of a disease, comprising the steps of:
- a) providing a saliva sample from a subject;
b) isolating a mucin in said saliva sample to produce an isolated mucin; and
c) quantitating the content of a component of said isolated mucin to predict the risk of a disease in said subject.
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Abstract
This present invention provides compositions and methods for assessing the risk of a disease using salivary analysis. Specifically, the present invention provides a method for predicting the risk of a disease, comprising the steps of: a) providing a saliva sample from a subject; b) isolating a mucin in the saliva sample to produce an isolated mucin; and c) quantitating the content of a component in the isolated mucin, to predict the risk of a disease in the subject. The present invention also provides methods for reducing the risk of a disease and diagnostic kits for detecting a disease based on measurement of the content of a component in a salivary mucin.
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Citations
71 Claims
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1. A method for predicting the risk of a disease, comprising the steps of:
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a) providing a saliva sample from a subject;
b) isolating a mucin in said saliva sample to produce an isolated mucin; and
c) quantitating the content of a component of said isolated mucin to predict the risk of a disease in said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for reducing the risk of a disease, comprising the steps of:
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a) providing a saliva sample from a subject;
b) isolating a mucin in said saliva sample to produce an isolated mucin;
c) quantitating the content of a component in said isolated mucin; and
d) administering a therapeutic reagent to said subject when the content of said component in said isolated mucin significantly falls below the level expressed in an oral fluid standard. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A diagnostic kit for detecting a disease comprising:
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a) a means for collecting a saliva sample;
b) a means for isolating a mucin in said saliva sample, to produce an isolated mucin;
c) a means for measuring the amount of a component in said isolated mucin; and
d) an oral fluid standard for comparing the amount of said component in said isolated mucin. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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Specification