Method and apparatus for determining spatial relation of multiple implantable electrodes

• US 20030040676A1
• Filed: 04/25/2002
• Published: 02/27/2003
• Est. Priority Date: 05/03/2001
• Status: Abandoned Application

• Current Assignee: Quetzal Biomedical, Inc.
• Original Assignee: Quetzal Biomedical, Inc.
• Inventors: Costello, Jim, Fuka, Mary Z., Prentice, John A.
• Application Number:
  US10/132,862
• Publication Number:
  US 20030040676A1
• Time in Patent Office: Days
• US Class Current: 600/508
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

An apparatus and method to determine the relative locations of a set of implantable electrodes, preferably five or more, which can be positioned in a chamber of the heart or within another organ or chamber. At least two electrodes are configured to be a known distance from each other. A signal generation apparatus provides a signal having a frequency through a set of pairs of electrodes. This signal is detected on all other electrodes. Additional pairs of signal-emitting electrodes are selected and measurements are made on all other electrodes until sufficient sets of data have been acquired specify a set of equations. Solution of the sets of equations by numerical methods provides the relative locations of the electrodes in a dielectric medium. Where the electrodes are implanted in an environment comprising dielectric media of differing characteristics, such as blood and myocardial tissue, the signal generation apparatus is capable of producing signals at multiple frequencies. Sets of equations are acquired for multiple frequencies. Solutions of the equations derived from each of the sets of equations are combined to eliminate the effect of a non-uniform dielectric medium. Alternatively, the effect of differing media can be eliminated by calculating position vectors for image charges or virtual electrodes. Location of a dielectric boundary, such as the myocardial wall, may be determined.

Claims

1. A method for determining a spatial relationship between a plurality of electrodes implanted in a human body comprising

placing a set of at least five electrodes in a cavity in the body;

designating a first electrode as an origin;

designating a second electrode defining a first axis,

selecting a third electrode, said third electrode being non-colinear with said first and second electrodes, said third electrode defining a second axis,

defining a third axis related to said first and second axes;

generating a periodic signal having a frequency between two signal-generating electrodes,

measuring said signal at pairs of electrodes taken from said set of electrodes, excluding said two signal generating electrodes; and

determining a location vector for each electrode from said measured signals.

2. The method of claim 1 wherein said first and second electrodes are separated by a known distance.

3. The method of claim 1 wherein measuring said signal at pairs of electrodes further comprises measuring at every electrode at least once.

4. The method of claim 1 wherein determining a location vector for each electrode further comprises determining a location vector for each real electrode and determining a location vector for a virtual electrode associated with a real electrode.

5. The method of claim 4 further comprising determining the location of a dielectric boundary between a real electrode and a virtual electrode associated with said real electrode.

6. The method of claim 1 wherein said step of measuring comprises acquiring a plurality of sample measurements for each unique pair during a period of time when said signal is generated between said signal-generating electrodes.

7. The method of claim 6 wherein said step of determining a location vector comprises solving a set of non-linear equations.

8. The method of claim 6 wherein the step of determining a location vector further comprises fitting said plurality of sample measurements for a unique pair to obtain a set of coefficients characterizing said signal at said unique pair.

9. The method of claim 8 wherein said step of determining a location vector comprises solving a set of non-linear equations comprising said coefficients.

10. The method of claim 6 wherein said step of measuring further comprises measuring during two or more periods of time.

11. The method of claim 10 wherein the step of determining a location vector further comprises fitting said plurality of sample measurements from said two or more periods of time for a unique pair to obtain a set of coefficients characterizing said signal at said unique pair.

12. The method of claim 11 wherein said step of determining a location vector comprises solving a set of non-linear equations comprising said coefficients.

13. The method of claim 1 further comprising selecting a plurality of unique pairs of signal generating electrodes and repeating said step of measuring said signal for each unique pair of signal generating electrodes.

14. The method of claim 13 wherein all electrodes are used as signal-generating electrodes.

15. The method of claim 13 wherein said set of at least five electrodes comprises at least six electrodes and less than all electrodes are used as signal generating electrodes.

16. The method of claim 15 wherein said set of at least six electrodes comprises six or seven electrodes and at least three electrodes are used as signal generating electrodes.

17. The method of claim 1 wherein said chamber comprises a first region filled with blood or body fluids having a first set of dielectric properties and a chamber wall comprising a second region having a second set of dielectric properties.

18. The method of claim 17 further comprising generating said signal in a range where the dielectric properties of said first and second regions are substantially equivalent.

19. The method of claim 17 further comprising

selecting a set of test frequencies,

determining location vectors for each electrode using at least two frequencies,

finding a difference between location vectors determined using one frequency and location vectors using another frequency,

selecting one of said location vectors when said difference is less than a pre-selected value, and

determining a new location vector using a further frequency from said set of test frequencies when said difference is greater than said pre-selected value.

20. The method of claim 19 further comprising

projecting said location vectors as a function of frequency to a frequency range where said first and second regions have substantially equivalent dielectric properties and

determining a projected location vector at a frequency in said frequency range.

21. The method of claim 17 further comprising

selecting a set of test frequencies,

determining location vectors for each electrode using at at least some of frequencies,

projecting said location vectors as a function of frequency to a frequency range where said first and second regions have substantially equivalent dielectric properties, and

determining a projected location vector at a frequency in said frequency range.

27. The apparatus of claim 1 further comprising means for acquiring a plurality of sample measurements for each unique pair during a period of time when said signal is generated between said signal-generating electrodes.

28. The apparatus of claim 27 further comprising a digital computer for solving a set of non-linear equations to determine a location vector.

29. The apparatus of claim 27 further comprising means for determining a location vector further comprises fitting said plurality of sample measurements for a unique pair to obtain a set of coefficients characterizing said signal at said unique pair.

30. The apparatus of claim 29 further comprising means for solving a set of non-linear equations comprising said coefficients.

31. The apparatus of claim 27 wherein said means for measuring further comprises means for measuring during two or more periods of time.

32. The apparatus of claim 31 further comprising means for fitting said plurality of sample measurements from said two or more periods of time for a unique pair to obtain a set of coefficients characterizing said signal at said unique pair.

33. The apparatus of claim 32 further comprising means for solving a set of non-linear equations comprising said coefficients.

42. The apparatus of claim 31 further comprising

means for selecting a set of test frequencies, and

means for projecting location vectors as a function of frequency to a frequency range where said first and second regions have substantially equivalent dielectric properties.

22. An apparatus for determining a spatial relationship between a plurality of electrodes implanted in a human body, said apparatus comprising

a set of at least five electrodes mounted on at least one lead and implanted in a chamber in the body, a first one of said two electrodes being an origin and said first and second electrodes defining a first axis;

and a third electrode non-colinear with said first and second electrodes, said third electrode defining a second axis,

a signal generator producing a periodic signal having a frequency, said signal generator being selectively connected between two signal-generating electrodes,

a voltage measuring device, said signal measuring device being selectively connected to pairs of electrodes taken from said set of electrodes, excluding said two signal generating electrodes; and

means for determining a location vector for each electrode from said measured signals.

23. The apparatus of claim 22 wherein said first and second electrodes are separated by a known distance.

24. The apparatus of claim 22 further comprising means for measuring at every electrode at least once.

25. The apparatus of claim 22 further comprising means for determining a location vector for each real electrode and means for determining a location vector for a virtual electrode associated with each real electrode.

26. The apparatus of claim 25 further comprising means for determining the location of a dielectric boundary between a real electrode and a virtual electrode associated with said real electrode.

34. The apparatus of claim 22 further comprising means for selecting a plurality of unique pairs of signal generating electrodes and means for repeatedly measuring said signal for each unique pair of signal generating electrodes.

35. The apparatus of claim 34 wherein all electrodes are used connectable to said signal generator.

36. The apparatus of claim 34 comprising at least six electrodes and less than all electrodes are connected to said signal generator.

37. The apparatus of claim 22 wherein said dielectric medium comprises a first region having a first set of dielectric properties and a second region having a second set of dielectric properties.

38. The apparatus of claim 37 wherein said signal generator can generate signals in a range where the dielectric properties of said first and second regions are substantially equivalent.

39. The apparatus of claim 38 wherein said signal generator can generate signals in excess of 100 MHz.

40. The apparatus of claim 37 further comprising

means for selecting a set of test frequencies,

means for finding a difference between location vectors determined using one frequency and location vectors using another frequency, and

means for selecting one of said location vectors when said difference is less than a pre-selected value.

41. The apparatus of claim 40 further comprising

means for projecting said location vectors as a function of frequency to a frequency range where said first and second regions have substantially equivalent dielectric properties.

43. A method for determining a spatial relationship between a plurality of electrodes in a dielectric medium comprising

placing a set of at least five electrodes in a dielectric medium;

designating a first electrode as an origin;

designating a direction from said first electrode to a second electrode as a first axis,

selecting a third electrode, said third electrode being non-colinear with said first and second electrodes, said third electrode defining a second axis,

defining a third axis related to said first and second axes;

generating a periodic signal having a frequency between two signal-generating electrodes,

measuring said signal at pairs of electrodes taken from said set of electrodes, excluding said two signal generating electrodes; and

determining a location vector for each electrode from said measured signals.

44. An apparatus for determining a spatial relationship between a plurality of electrodes in a dielectric medium comprising

a set of at least five electrodes in a dielectric medium,

a first electrode defining an origin and a second electrode defining a first axis from said origin;

a third electrode, said third electrode being non-colinear with said first and second electrodes, said third electrode defining a second axis,

a signal generator producing a periodic signal having a frequency, said signal generator being selectively connected between two signal-generating electrodes,

a voltage measuring device, said signal measuring device being selectively connected to pairs of electrodes taken from said set of electrodes, excluding said two signal-generating electrodes; and

means for determining a location vector for each electrode from said measured signals.