Apparatus and method for in vivo delivery of therapeutic agents
First Claim
1. A device for administering a therapeutic agent, including an agent permeable membrane having a pair of contact electrodes, such that when the device is contacted to a site of administration, the agent permeable membrane directly contacts the site of administration.
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Accused Products
Abstract
Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.
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Citations
55 Claims
- 1. A device for administering a therapeutic agent, including an agent permeable membrane having a pair of contact electrodes, such that when the device is contacted to a site of administration, the agent permeable membrane directly contacts the site of administration.
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31. An electrode membrane device including:
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(a) an adhesive layer, (b) an agent permeable membrane attached to the adhesive layer, (c) a first electrode affixed to the agent permeable membrane, (d) a therapeutic agent, (e) a pharmaceutical composition including one or more non-biologically active substances and the therapeutic agent, (f) a casing which forms a reservoir between the agent permeable membrane and the casing where the reservoir contains the pharmaceutical composition, and (g) a second electrode affixed to the casing.
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32. A method of in vivo administration of a therapeutic agent including the following steps:
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(a) contacting a device which includes an agent permeable membrane having a pair of contact electrodes to a site of administration, such that the agent permeable membrane directly contacts the site of administration, (b) applying a therapeutic agent to the agent permeable membrane, and (c) applying an electric signal to the contact electrodes. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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39. A method of in vivo administration of a therapeutic agent including the following steps:
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(a) contacting a device which includes an agent permeable membrane having a pair of contact electrodes to a site of administration such that the agent permeable membrane directly contacts the site of administration, a casing attached to the agent permeable membrane forming a reservoir, a pharmaceutical composition including the therapeutic agent where the pharmaceutical composition is contained in the reservoir, an iontophoretic electrode which is located in the reservoir;
(b) contacting a counter electrode to a second site;
(c) applying a first electric signal to the contact electrodes; and
(d) applying a second electric signal to the iontophoretic electrode. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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53. A device for administering a therapeutic agent, comprising:
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an electrode cup, including an electrode and a rim; and
an electrode membrane attached to the rim of the electrode cup, including a permeable membrane and a pair of electrodes imprinted into the permeable membrane. - View Dependent Claims (54, 55)
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Specification