Stent coating
First Claim
1. An expandable stent for use within in a body passageway including a body member, a intermediate compound, and a biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said body member having a first cross-sectional shape having a first cross-sectional area which permits intraluminal delivery of said body member into the body cavity, and a second expanded cross-sectional shape having a second cross-sectional area which is greater than said first cross-sectional area, said biological agent at least partially coated on the surface of said body member, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including at least one radiation induced cross-linking that at least partially encapsulates at least a portion of said biological agent in said intermediate compound.
4 Assignments
0 Petitions
Accused Products
Abstract
An expandable stent for use within a body passageway having a body member with two ends and a wall surface disposed between the ends. The body member has a first diameter to permit delivery of the body member into a body passageway and a second expanded diameter. The surface of the stent is coated with a biological agent and a polymer which controls the release of the biological agent.
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Citations
67 Claims
- 1. An expandable stent for use within in a body passageway including a body member, a intermediate compound, and a biological agent, said body member having first and second ends and a wall surface disposed between said first and second ends defining a longitudinal axis of said body member, said body member having a first cross-sectional shape having a first cross-sectional area which permits intraluminal delivery of said body member into the body cavity, and a second expanded cross-sectional shape having a second cross-sectional area which is greater than said first cross-sectional area, said biological agent at least partially coated on the surface of said body member, said intermediate compound at least partially securing said biological agent to said body member, said intermediate compound including at least one radiation induced cross-linking that at least partially encapsulates at least a portion of said biological agent in said intermediate compound.
- 52. A biological matrix comprising a base compound and biological agent, said base compound including a polymer, copolymer or mixtures thereof, said base compound at least partially encapsulating at least a portion of said biological agent, said base compound including at least one radiation induced cross-linking, said at least one radiation induced cross-linking at least partially entrapping said biological agent in said base compound.
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60. A method for producing an expandable stent coated with a biological agent comprising:
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a) selecting a stent having a body member, said body member having a first cross-sectional shape having a first cross-sectional area which permits intraluminal delivery of said body member into the body cavity, and a second expanded cross-sectional shape having a second cross-sectional area which is greater than said first cross-sectional area;
b) coating at least a portion of said body member with a mixture of an intermediate compound and a biological agent, said intermediate compound including polymer, copolymer and combinations thereof; and
,c) applying radiation to said coating to cause at least one cross-link to form in said intermediate compound that at least partially encapsulates at least a portion of said biological agent in said intermediate compound. - View Dependent Claims (61, 62, 63)
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64. A method for producing an expandable stent coated with a biological agent comprising:
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a) selecting a stent having a body member, said body member having a first cross-sectional shape having a first cross-sectional area which permits intraluminal delivery of said body member into the body cavity, and a second expanded cross-sectional shape having a second cross-sectional area which is greater than said first cross-sectional area;
b) coating at least a portion of said body member with a mixture of an intermediate compound and a biological agent, said intermediate compound including polymer, copolymer and combinations thereof; and
,c) applying radiation to said coating to cause at least one salt complex to form between intermediate compound and said biological agent. - View Dependent Claims (65, 66, 67)
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Specification