Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release
First Claim
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1. A formulation comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises:
- a gas-filled microsphere;
at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and
liquid-filled liposomes attached to the lipid or surfactant.
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Abstract
Formulations comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises: a gas-filled microsphere; at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and liquid-filled liposomes attached to the lipid or surfactant are described. Methods of preparing the same and using them in ultrasound imaging are also described. The present invention also comprises use of the same in treating heart disease, inflammation, infection, cancer or thromboembolic disease in a patient
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Citations
72 Claims
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1. A formulation comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises:
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a gas-filled microsphere;
at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and
liquid-filled liposomes attached to the lipid or surfactant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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69. A formulation comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises:
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a gas-filled microsphere;
at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and
liquid-filled liposomes attached to the lipid or surfactant;
for use in medical therapy or diagnosis.
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70. The use of a formulation comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises:
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a gas-filled microsphere;
at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and
liquid-filled liposomes attached to the lipid or surfactant;
for the manufacture of a medicament for treating heart disease, inflammation, infection, cancer or thromboembolic disease in a patient in need of such treatment.
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71. The use of a formulation comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises:
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a gas-filled microsphere;
at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and
liquid-filled liposomes attached to the lipid or surfactant;
for the manufacture of a medicament for diagnostic imaging in a patient in need of such diagnostic imaging.
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72. The use of a formulation comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises:
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a gas-filled microsphere;
at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and
liquid-filled liposomes attached to the lipid or surfactant;
for the manufacture of a medicament for ultrasound imaging in a patient in need of such ultrasound imaging.
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Specification