Coating for use with medical devices and method of making same
First Claim
1. A flexible coating, the coating comprising:
- RTV silicone and urethane.
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Abstract
The inventive coating may be employed to deliver a pharmaceutical agent to a selected body area that is involved within the insertion or application of a medical device. Such medical devices may include silicone based urinary catheters and other medical implants as well as other silicone based devices having deformable portions which could benefit from the release of a pharmaceutical agent from its surface. The coating allows the introduction of the pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria. The release rate is adjusted by utilizing different salt forms of the additive and adjusting the concentration of urethane and RTV silicone. The coating incorporates additive compounds such as anti-microbial, anti-fungals and other organic compounds. Methods are also provided for the manufacture of the subject coating and for the application of the same to surfaces of medical devices.
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Citations
45 Claims
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1. A flexible coating, the coating comprising:
- RTV silicone and urethane.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- 15. A flexible coating including RTV silicone and urethane for a silicone based medical device, the flexible coating being disposed on a deformable surface of the silicone based medical device and retaining adhesion to the deformable surface.
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29. A method for producing a coating for a medical article comprising:
- blending RTV silicone, urethane, and a solvent until dissolved.
- View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A method of controlling the release rate of a medicinal additive from a coating vehicle comprising:
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providing a coating vehicle including urethane, RTV silicone and a medicinal additive;
determining a therapeutic dosing range of the pharmacological additive;
determining pharmacokinetic properties of the pharmacological additive; and
adjusting concentration of the urethane to the RTV silicone to achieve a desired release rate.
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45. A method of producing a flexible coating having a medicinal additive comprising:
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forming a first solution by blending about 0.5 percent to 10 percent by weight urethane with about 90 percent to 99.5 percent by weight of a first solvent;
forming a second solution by blending about 0.5 percent to 5.0 percent by weight of a medicinal compound with about 95 percent to 99.5 percent by weight of a second solvent;
combining 15 percent to 60 percent by weight of the first solution with 40 to 85 percent by weight of the second solution forming a third solution; and
incorporating about 0.5 percent to 10 percent by weight of a RTV silicone into the third solution.
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Specification