FLOWTHROUGH DEVICES FOR MULTIPLE DISCRETE BINDING REACTIONS
First Claim
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1. A device for binding a target molecule, comprising:
- a substrate having oppositely facing first and second major surfaces;
a multiplicity of discrete channels extending through said substrate from said first major surface to said second major surface;
a first binding reagent immobilized in a first group of said channels, and a second binding reagent immobilized in a second group of said channels.
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Abstract
Devices and methods for conducting binding reactions are described. The devices comprise first and second surfaces with channels extending between them. Specific binding reagents are immobilized in discrete groups of the channels. Sample passing through the channels reacts with the binding reagents. Binding of the sample component to the binding reagent in different groups of channels is detected providing information about sample composition. The devices provide increased surface area and accelerated reactions kinetics compared with flat surfaces.
167 Citations
39 Claims
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1. A device for binding a target molecule, comprising:
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a substrate having oppositely facing first and second major surfaces;
a multiplicity of discrete channels extending through said substrate from said first major surface to said second major surface;
a first binding reagent immobilized in a first group of said channels, and a second binding reagent immobilized in a second group of said channels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 38)
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20. A device for binding a target molecule, comprising:
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a substrate having oppositely facing first and second major surfaces;
a multiplicity of discrete channels extending through said substrate from said first major surface to said second major surface;
a first binding reagent immobilized in a first group of said channels, and a second binding reagent immobilized in a second group of said channels, further comprising a rigid support, wherein said rigid support is integral to said substrate, or is bonded to said substrate. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 39)
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Specification