Cartridge for biochemical analysis unit and method for recording biochemical analysis data in biochemical analysis unit

• US 20030045002A1
• Filed: 08/21/2002
• Published: 03/06/2003
• Est. Priority Date: 08/28/2001
• Status: Abandoned Application

• Current Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Original Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Inventors: Muraishi, Katsuaki
• Application Number:
  US10/224,376
• Publication Number:
  US 20030045002A1
• Time in Patent Office: Days
• US Class Current: 436/514
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing

Abstract

A cartridge for a biochemical analysis unit is adapted for accommodating a biochemical analysis unit and formed with at least one fluid passage for leading a solution to only a plurality of absorptive regions formed in the biochemical analysis unit to be spaced apart from each other. According to thus constituted cartridge, it is possible to forcibly and uniformly feed a reaction solution containing a ligand or a receptor labeled with a labeling substance to the plurality of absorptive regions of the biochemical analysis unit, thereby associating the ligand or the receptor contained in the reaction solution with a receptor or a ligand fixed in the absorptive regions of the biochemical analysis unit. Therefore, it is possible to extremely efficiently associate the ligand or the receptor contained in the reaction solution with the receptor or the ligand fixed in the absorptive regions of the biochemical analysis unit.

Claims

1. A cartridge for a biochemical analysis unit being adapted for accommodating a biochemical analysis unit and formed with at least one fluid passage for leading a solution to only a plurality of absorptive regions formed in the biochemical analysis unit to be spaced apart from each other.

2. A cartridge for a biochemical analysis unit in accordance with claim 1 wherein the at least one fluid passage is formed so as to cut through the plurality of absorptive regions formed in the biochemical analysis unit to be spaced apart from each other.

3. A cartridge for a biochemical analysis unit in accordance with claim 1 wherein a plurality of fluid passages are formed.

4. A cartridge for a biochemical analysis unit in accordance with claim 1 wherein the plurality of absorptive regions are two-dimensionally formed in the biochemical analysis unit to be spaced apart from each other and a fluid passage is formed for each line of the plurality of absorptive regions so that the fluid passage can successively lead a solution to the plurality of absorptive regions constituting each line.

5. A cartridge for a biochemical analysis unit in accordance with claim 4 wherein the fluid passage formed for each line of the plurality of absorptive regions is formed so as to sequentially cross the absorptive regions constituting the line.

6. A cartridge for a biochemical analysis unit in accordance with claim 4 wherein the plurality of fluid passages are disposed on one side of the biochemical analysis unit held in the cartridge.

7. A cartridge for a biochemical analysis unit in accordance with claim 1 wherein the plurality of absorptive regions are two-dimensionally formed in the biochemical analysis unit to be spaced apart from each other and a fluid passage is formed for each of the absorptive regions so as to feed a solution thereto.

8. A cartridge for a biochemical analysis unit in accordance with claim 7 wherein the fluid passage formed for each of the absorptive regions is formed so as to cut through the corresponding absorptive region.

9. A cartridge for a biochemical analysis unit in accordance with claim 7 wherein the fluid passage formed for each of the absorptive regions is disposed on one side of the biochemical analysis unit held in the cartridge.

10. A cartridge for a biochemical analysis unit in accordance with claim 2 wherein a portion of the fluid passage facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

11. A cartridge for a biochemical analysis unit in accordance with claim 5 wherein a portion of the fluid passage facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

12. A cartridge for a biochemical analysis unit in accordance with claim 8 wherein a portion of the fluid passage facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

13. A cartridge for a biochemical analysis unit in accordance with claim 2 wherein a portion of the fluid passage facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.5 mm² or less.

14. A cartridge for a biochemical analysis unit in accordance with claim 5 wherein a portion of the fluid passage facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.5 mm² or less.

15. A cartridge for a biochemical analysis unit in accordance with claim 8 wherein a portion of the fluid passage facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.5 mm² or less.

16. A method for recording biochemical analysis data in a biochemical analysis unit comprising the steps of accommodating a biochemical analysis unit including a substrate formed with a plurality of absorptive regions to be spaced apart from each other in which receptors or ligands are fixed in a cartridge and feeding a reaction solution containing a ligand or a receptor labeled with a labeling substance only to the absorptive regions of the biochemical analysis unit through at least one fluid passage formed in the cartridge, thereby selectively associating the ligand or the receptor contained in the reaction solution with the receptors or the ligands fixed in the plurality of the absorptive regions of the biochemical analysis unit.

17. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 which further comprises the step of feeding a cleaning solution only to the absorptive regions of the biochemical analysis unit through at least one fluid passage formed in the cartridge, thereby cleaning the plurality of absorptive regions of the biochemical analysis unit in which the receptors or the ligands are fixed with the cleaning solution.

18. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the at least one fluid passage is formed in the cartridge so as to cut through the plurality of absorptive regions formed in the biochemical analysis unit to be spaced apart from each other.

19. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 17 wherein the at least one fluid passage is formed in the cartridge so as to cut through the plurality of absorptive regions formed in the biochemical analysis unit to be spaced apart from each other.

20. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 18 wherein a plurality of fluid passages are formed in the cartridge correspondingly to the plurality of absorptive regions formed in the biochemical analysis unit.

21. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 19 wherein a plurality of fluid passages are formed in the cartridge correspondingly to the plurality of absorptive regions formed in the biochemical analysis unit.

22. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the plurality of absorptive regions are two-dimensionally formed in the biochemical analysis unit to be spaced apart from each other and a fluid passage is formed in the cartridge for each line of the plurality of absorptive regions so that the fluid passage can successively lead a solution to the plurality of absorptive regions constituting each line.

23. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 17 wherein the plurality of absorptive regions are two-dimensionally formed in the biochemical analysis unit to be spaced apart from each other and a fluid passage is formed in the cartridge for each line of the plurality of absorptive regions so that the fluid passage can successively lead a solution to the plurality of absorptive regions constituting each line.

24. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 22 wherein the fluid passage formed for each line of the plurality of absorptive regions is formed so as to sequentially cut through the absorptive regions constituting the line.

25. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 23 wherein the fluid passage formed for each line of the plurality of absorptive regions is formed so as to sequentially cut through the absorptive regions constituting the line.

26. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 22 wherein the plurality of fluid passages are formed in the cartridge so as to be disposed on one side of the biochemical analysis unit held in the cartridge.

27. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 23 wherein the plurality of fluid passages are formed in the cartridge so as to be disposed on one side of the biochemical analysis unit held in the cartridge.

28. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the plurality of absorptive regions are two-dimensionally formed in the biochemical analysis unit to be spaced apart from each other and a fluid passage is formed in the cartridge for each of the absorptive regions so as to feed a solution thereto.

29. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 17 wherein the plurality of absorptive regions are two-dimensionally formed in the biochemical analysis unit to be spaced apart from each other and a fluid passage is formed in the cartridge for each of the absorptive regions so as to feed a solution thereto.

30. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 28 wherein the fluid passage formed for each of the absorptive regions is formed so as to cut through the corresponding absorptive region.

31. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 29 wherein the fluid passage formed for each of the absorptive regions is formed so as to cut through the corresponding absorptive region.

32. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 28 wherein the fluid passage formed for each of the absorptive regions is disposed on one side of the biochemical analysis unit held in the cartridge.

33. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 29 wherein the fluid passage formed for each of the absorptive regions is disposed on one side of the biochemical analysis unit held in the cartridge.

34. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 18 wherein the at least one fluid passage is formed in the cartridge so that a portion thereof facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

35. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 19 wherein the at least one fluid passage is formed in the cartridge so that a portion thereof facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

36. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 24 wherein the fluid passage formed for each line of the plurality of absorptive regions is formed so that a portion thereof facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

37. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 25 wherein the fluid passage formed for each line of the plurality of absorptive regions is formed so that a portion thereof facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

38. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 30 wherein the fluid passage formed for each of the absorptive regions is formed so that a portion thereof facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

39. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 31 wherein the fluid passage formed for each of the absorptive regions is formed so that a portion thereof facing the absorptive region of the biochemical analysis unit has a cross sectional area of 0.2 mm² or less.

40. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 26 wherein the at least one fluid passage is formed in the cartridge on one side of the biochemical analysis unit held in the cartridge so that a portion thereof facing the absorptive region of the biochemical analysis unit has a length of 0.5 mm or less.

41. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 27 wherein the at least one fluid passage is formed in the cartridge on one side of the biochemical analysis unit held in the cartridge so that a portion thereof facing the absorptive region of the biochemical analysis unit has a length of 0.5 mm or less.

42. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 32 wherein the fluid passage formed for each of the absorptive regions is disposed on one side of the biochemical analysis unit held in the cartridge so that a portion thereof facing the absorptive region of the biochemical analysis unit has a length of 0.5 mm or less.

43. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 33 wherein the fluid passage formed for each of the absorptive regions is disposed on one side of the biochemical analysis unit held in the cartridge so that a portion thereof facing the absorptive region of the biochemical analysis unit has a length of 0.5 mm or less.

44. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the substrate of the biochemical analysis unit is formed with a plurality of holes to be spaced apart from each other and the plurality of absorptive regions of the biochemical analysis unit are formed by charging an absorptive material in the plurality of holes formed in the substrate.

45. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the substrate of the biochemical analysis unit is formed with 10 or more absorptive regions.

46. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein each of the plurality of absorptive regions formed in the substrate of the biochemical analysis unit has a size of less than 5 mm².

47. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 10 or more per cm².

48. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the substrate of the biochemical analysis unit has a property of attenuating radiation energy.

49. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 48 wherein the substrate of the biochemical analysis unit has a property of reducing the energy of radiation to ⅕

or less when the radiation travels in the substrate by a distance equal to that between neighboring absorptive regions.

50. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 16 wherein the substrate of the biochemical analysis unit has a property of attenuating light energy.

51. A method for recording biochemical analysis data in a biochemical analysis unit in accordance with claim 50 wherein the substrate of the biochemical analysis unit has a property of reducing the energy of light to ⅕

or less when the light travels in the substrate by a distance equal to that between neighboring absorptive regions.