Time-delay integration imaging of biological specimen
First Claim
Patent Images
1. A method for imaging biological specimens using an imaging chip having rows and columns, the method comprising:
- capturing a pixel image of an object on the specimens;
shifting the pixel image in the columnar direction of the imaging chip;
moving the object in synchronous motion with the pixel image; and
reading out voltage values from the bottom row of the imaging chip until a plurality of the specimens are imaged.
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Abstract
A biological sample is scanned with Time-Delay Integration (TDI) by a CCD camera having columns and rows. When the light from a location of the sample falls onto a picture element (pixel) on the camera, the photons of the light are converted to electrons. The electrons within that pixel are shifted down one row to the pixel directly beneath it. The shifts occur in the columnar direction of the camera while the sample is moved synchronously with the electrons. The electrons shifted off the bottom row of the camera are measured and converted into a digital value for that picture element in the sample image.
42 Citations
30 Claims
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1. A method for imaging biological specimens using an imaging chip having rows and columns, the method comprising:
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capturing a pixel image of an object on the specimens;
shifting the pixel image in the columnar direction of the imaging chip;
moving the object in synchronous motion with the pixel image; and
reading out voltage values from the bottom row of the imaging chip until a plurality of the specimens are imaged. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for imaging a sample using an imaging device, the method comprising:
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moving the position of an image area on the sample along one dimension of the device;
imaging a spot on the image area continuously until the imaged spot is moved out of the detection range of the device; and
adjusting the speed of the movement for adequate exposure time. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification