Pharmaceutical composition
First Claim
1. A composition comprising:
- (A) a pharmaceutical compound;
(B) a membrane-compatible permeation enhancer; and
(C) a polymeric film-forming agent.
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Accused Products
Abstract
A composition comprising a pharmaceutical compound, a membrane-permeation enhancer, and a polymeric film-forming agent, including, for example, a hydrocarbon-based liquid nail lacquer comprising a solution of an anti-fungal agent in a pharmaceutically-effective amount, a membrane-compatible permeation enhancer in an amount effective to enhance penetration through a membrane or nail of said anti-fungal agent, a polymeric film-forming agent in an amount effective to form an adherent polymeric film on a membrane or nail, and a solvent for forming said solution; and a method for forming on a membrane or nail of the body an adherent film containing a pharmaceutical compound and permeation enhancer from a solution of the components in which there is used a mixture of solvents, including a solvent which is highly volatile and a solvent of lower volatility.
114 Citations
28 Claims
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1. A composition comprising:
- (A) a pharmaceutical compound;
(B) a membrane-compatible permeation enhancer; and
(C) a polymeric film-forming agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 21, 22, 23, 24, 25, 26, 27, 28)
- (A) a pharmaceutical compound;
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15. A hydrocarbon-based liquid nail lacquer comprising a solution of:
- (A) an anti-fungal agent in a pharmaceutically-effective amount;
(B) a membrane-compatible permeation enhancer in an amount effective to enhance penetration through a membrane or nail of said anti-fungal agent;
(C) a polymeric film-forming agent in an amount effective to form an adherent polymeric film on a membrane or nail; and
(D) solvent for forming said solution. - View Dependent Claims (16)
- (A) an anti-fungal agent in a pharmaceutically-effective amount;
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17. A method for administering a pharmaceutical compound to the body through the nail or membrane of the body comprising:
- (A) applying to the nail or membrane a liquid composition comprising a pharmaceutical compound, a membrane-compatible permeation enhancer, and a polymeric film-forming agent;
(B) forming from said liquid composition a solid film which adheres to the nail or membrane; and
(C) maintaining said film on the nail or membrane for a period of time sufficient for delivery of the pharmaceutical compound to the body through the nail or membrane. - View Dependent Claims (18)
- (A) applying to the nail or membrane a liquid composition comprising a pharmaceutical compound, a membrane-compatible permeation enhancer, and a polymeric film-forming agent;
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19. A method for forming on a membrane or a nail solid adherent film comprising a pharmaceutical compound and an enhancer therefore comprising:
- (A) providing a solution in which the pharmaceutical compound, the enhancer, and a polymeric film-forming agent are dissolved, the solution containing a co-solvent which includes;
(i) a highly volatile solvent for the enhancer in which the enhancer is highly soluble; and
(ii) a less volatile solvent in which the enhancer is less soluble; and
(B) applying said soluble solution to the nail or membrane;
(C) forming from said solution a solid film which includes the pharmaceutical compound and the enhancer by permitting the highly volatile solvent to evaporate at a faster rate than the solvent having lower volatility; and
(D) drying the resulting film. - View Dependent Claims (20)
- (A) providing a solution in which the pharmaceutical compound, the enhancer, and a polymeric film-forming agent are dissolved, the solution containing a co-solvent which includes;
Specification