Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
First Claim
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1. A method for treating a non-allergic inflammatory disease, comprising:
- administering to a subject having or at risk of developing a non-allergic inflammatory disease a therapeutically effective amount of an immunostimulatory nucleic acid to treat or prevent the non-allergic inflammatory disease.
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Abstract
The invention provides methods and compositions for using immunostimulatory nucleic acids to treat non-allergic inflammatory diseases. Non-allergic inflammatory diseases that may be treated according to the methods and products of the invention include psoriasis and inflammatory bowel disease. The invention further provides methods for augmenting a Th1 response to immunostimulatory nucleic acid involving inhibition of prostaglandin-mediated counter-regulatory response.
278 Citations
100 Claims
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1. A method for treating a non-allergic inflammatory disease, comprising:
administering to a subject having or at risk of developing a non-allergic inflammatory disease a therapeutically effective amount of an immunostimulatory nucleic acid to treat or prevent the non-allergic inflammatory disease. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for treating inflammatory bowel disease, comprising:
administering to a subject having or at risk of developing an inflammatory bowel disease a therapeutically effective amount of an immunostimulatory nucleic acid to treat or prevent the inflammatory bowel disease. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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60. A pharmaceutical composition, comprising:
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an immunostimulatory nucleic acid in an effective amount for preventing or treating an immune or inflammatory response associated with a non-allergic inflammatory disease, a non-allergic inflammatory disease medicament, and a pharmaceutically acceptable carrier. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74)
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75. A pharmaceutical composition, comprising:
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an immunostimulatory nucleic acid in an effective amount for preventing or treating an immune or inflammatory response associated with a non-allergic inflammatory disease, and a pharmaceutically acceptable carrier, wherein the immunostimulatory nucleic acid and pharmaceutically acceptable carrier are prepared in a formulation selected from the group consisting of;
a lotion, a cream, an ointment, and a gel. - View Dependent Claims (76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91)
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92. A method of augmenting Th1-like immune activation induced by an immunostimulatory nucleic acid, comprising:
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contacting an immune cell with an effective amount of an immunostimulatory nucleic acid to induce Th1-like immune activation; and
contacting the immune cell with an inhibitor of cyclooxygenase-2 (COX-2) expression, in an amount effective to augment Th1-like immune activation induced by the immunostimulatory nucleic acid. - View Dependent Claims (93)
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94. A method of augmenting Th1-like immune activation induced by an immunostimulatory nucleic acid, comprising:
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contacting an immune cell with an effective amount of an immunostimulatory nucleic acid to induce Th1-like immune activation; and
contacting the immune cell with an agent that inhibits PGE2 signaling through its receptor, in an amount effective to augment the Th1-like immune activation induced by the immunostimulatory nucleic acid. - View Dependent Claims (95, 96)
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97. A method of augmenting Th1-like immune activation in a subject, comprising:
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administering to a subject in need of Th1-like immune activation an effective amount of an immunostimulatory nucleic acid to induce Th1-like immune activation; and
administering to the subject an effective amount of a cyclooxygenase inhibitor to inhibit prostaglandin expression, wherein the subject is free of symptoms of asthma or allergy otherwise calling for treatment with immunostimulatory nucleic acid, and wherein Th1-like immune activation induced by administering the immunostimulatory nucleic acid and the cyclooxygenase inhibitor is greater than Th1-like immune activation induced by administering the immunostimulatory nucleic acid alone. - View Dependent Claims (98, 99, 100)
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Specification