Cancer therapy

• US 20030050297A1
• Filed: 01/22/2002
• Published: 03/13/2003
• Est. Priority Date: 01/19/2001
• Status: Abandoned Application

• Current Assignee: Aeolus Sciences Incorporated, Duke University, Goodnow Capital, L.L.C., National Jewish Medical and Research Center
• Original Assignee: Aeolus Sciences Incorporated
• Inventors: Vujaskovic, Zeljko, Day, Brian J., Batinic-Haberle, Ines, Crapo, James D., Gammans, Richard
• Application Number:
  US10/051,367
• Publication Number:
  US 20030050297A1
• Time in Patent Office: Days
• US Class Current: 514/185
• CPC Class Codes: A61K 31/409 having four such rings, e.g. porphine derivatives, bilirubin, biliverdine hemin, hematin A61K31/555
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants

Abstract

The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.

Claims

1. A method of treating cancer in a mammal comprising administering to a mammal in need thereof an amount of a mimetic of an enzymatic scavenger of reactive oxygen species sufficient to effect said treatment.

2. The method according to claim 1 wherein said mimetic is a mimetic of superoxide dismutase (SOD), catalase or peroxidase.

3. The method according to claim 2 wherein said mimetic is a mimetic of SOD.

4. The method according to claim 1 wherein said mimetic is a methine substituted porphine or substituted tetrapyrrole, or pharmaceutically acceptable salt thereof.

5. The method according to claim 1 wherein said mimetic is bound to a metal.

6. The method according to claim 5 wherein said metal is selected from the group consisting of manganese, iron, cobalt, copper, nickel and zinc.

7. The method according to claim 6 wherein said metal is manganese.

8. The method according to claim 7 wherein said mimetic is a manganese bound methine substituted porphine.

9. The method according to claim 8 wherein said mimetic is 10110, 10111, 10112, 10113, 10123, 10143, 10150, 10151, 10153, 10158 and 10201.

10. The method according to claim 2 wherein said mimetic is of the formula

11. A method of protecting normal tissue of a mammal from the toxic effects associated with gene therapy, immunotherapy, radiotherapy or chemotherapy comprising administering to a mammal in need thereof an amount of a mimetic of an enzymatic scavenger of reactive oxygen species sufficient to effect said treatment.

12. The method according to claim 11 wherein said mimetic is a mimetic of superoxide dismutase (SOD), catalase or peroxidase.

13. The method according to claim 12 wherein said mimetic is a mimetic of SOD.

14. The method according to claim 11 wherein said mimetic is a methine substituted porphine or substituted tetrapyrrole, or pharmaceutically acceptable salt thereof.

15. The method according to claim 11 wherein said mimetic is bound to a metal.

16. The method according to claim 15 wherein said metal is selected from the group consisting of manganese, iron, cobalt, copper, nickel and zinc.

17. The method according to claim 16 wherein said metal is manganese.

18. The method according to claim 17 wherein said mimetic is a manganese bound methine substituted porphine.

19. The method according to claim 18 wherein said mimetic is 10110, 10111, 10112, 10113, 10123, 10143, 10150, 10151, 10153, 10158 and 10201.

20. A method of preventing cancer or preventing the recurrence of cancer in a mammal comprising administering to a mammal in need thereof an amount of a mimetic of an enzymatic scavenger of reactive oxygen species sufficient to effect said treatment.

21. The method according to claim 20 wherein said mimetic is a mimetic of superoxide dismutase (SOD), catalase or peroxidase.

22. The method according to claim 21 wherein said mimetic is a mimetic of SOD.

23. The method according to claim 20 wherein said mimetic is a methine substituted porphine or substituted tetrapyrrole, or pharmaceutically acceptable salt thereof.

24. The method according to claim 20 wherein said mimetic is bound to a metal.

25. The method according to claim 24 wherein said metal is selected from the group consisting of manganese, iron, cobalt, copper, nickel and zinc.

26. The method according to claim 25 wherein said metal is manganese.

27. The method according to claim 26 wherein said mimetic is a manganese bound methine substituted porphine.

28. The method according to claim 27 wherein said mimetic is 10110, 10111, 10112, 10113, 10123, 10143, 10150, 10151, 10153, 10158 and 10201.