Non-invasive measurement of blood analytes using photodynamics
First Claim
1. A method for use in the determination of blood glucose in an individual comprising:
- (a) projecting illuminating light into an eye of the individual to illuminate the retina in the eye, the light having wavelengths that are absorbed by rhodopsin with the intensity of the light varying in a selected temporal manner;
(b) detecting the light reflected from the retina of the eye to provide a detected light signal corresponding to the intensity of the detected light; and
(c) analyzing the detected light signal to determine the distortion of the detected light relative to the illuminating light.
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Accused Products
Abstract
The determination of blood glucose in an individual is carried out by projecting illuminating light into an eye of the individual to illuminate the retina with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying in a prescribed temporal manner. The light reflected from the retina is detected to provide a signal corresponding to the intensity of the detected light, and the detected light signal is analyzed to determine the changes in form from that of the illuminating light. For a biased sinusoidal illumination, these changes can be expressed in terms of harmonic content of the detected light. The changes in form of the detected light are related to the ability of rhodopsin to absorb light and regenerate, which in turn is related to the concentration of blood glucose, allowing a determination of the relative concentration of blood glucose. Other photoreactive analytes can similarly be determined by projecting time varying illuminating light into the eye, detecting the light reflected from the retina, and analyzing the detected light signal to determine changes in form of the signal due to changes in absorptivity of a photoreactive analyte.
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Citations
28 Claims
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1. A method for use in the determination of blood glucose in an individual comprising:
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(a) projecting illuminating light into an eye of the individual to illuminate the retina in the eye, the light having wavelengths that are absorbed by rhodopsin with the intensity of the light varying in a selected temporal manner;
(b) detecting the light reflected from the retina of the eye to provide a detected light signal corresponding to the intensity of the detected light; and
(c) analyzing the detected light signal to determine the distortion of the detected light relative to the illuminating light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for use in the determination of a photoreactive blood analyte in an individual comprising:
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(a) projecting illuminating light into an eye of the individual to illuminate the retina in the eye, the light having wavelengths that are absorbed by the photoreactive analyte with the intensity of the light varying periodically at a selected frequency;
(b) detecting the light reflected from the retina of the eye to provide a detected light signal corresponding to the intensity of the detected light; and
(c) analyzing the detected light signal to determine a variation in the signal resulting from interaction of the illuminating light with the photoreactive analyte. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. Apparatus for use in determination of blood glucose in an individual comprising:
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(a) means for projecting illuminating light into an eye of an individual to illuminate the retina in the eye with the light having wavelengths that are absorbed by rhodopsin and with the intensity of the light varying periodically at a selected frequency; and
(b) means for detecting the light reflected from the retina of the eye and providing a detected light signal corresponding to the intensity of the detected light. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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Specification