Device and method to maintain vascularization near implant
First Claim
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1. An implantable hemofilter device, comprising:
- an implant body, and first cells, wherein the first cells produce at least one angiogenic product.
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Abstract
A device and a method of maintaining vascularization near an implant, especially a bioartificial hemofilter. By associating cells that excrete angiogenic factors with such an implant, vascularization to the tissue surrounding the implant can be maintained. In a bioartificial hemofilter, this facilitates filtrate transport to a collection fiber for drainage from the body. The cells can be genetically engineered, for example using an adenovirus vector encoding for vascular endothelial growth factor. Myoblasts and myotubes may be used in one embodiment of the present invention.
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Citations
95 Claims
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1. An implantable hemofilter device, comprising:
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an implant body, and first cells, wherein the first cells produce at least one angiogenic product. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 78, 79, 80, 81)
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50. A method of producing an implantable hemofilter device capable of maintaining vascularization when implanted, comprising:
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obtaining first cells capable of releasing an angiogenic product; and
associating the first cells with an implant body, wherein the first cells are capable of releasing the angiogenic product into a surroundings of implantable hemofilter device after implantation. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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82. An implantable hemofilter device, comprising:
means for maintaining vascularization in a surroundings of the implant. - View Dependent Claims (83, 84, 85, 86)
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87. A method of utilizing an ultrafiltrate produced by a filtration device, comprising:
transferring an ultrafiltrate produced by a fitration device implanted in a subject to a tissue-engineered construct which is also implanted in the subject. - View Dependent Claims (88, 89, 90, 91, 92, 93, 94, 95)
Specification