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Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production

  • US 20030055263A1
  • Filed: 07/10/2002
  • Published: 03/20/2003
  • Est. Priority Date: 07/11/2001
  • Status: Abandoned Application
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Assignment
First Claim
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1. Carboxylic acid derivatives of general formula R1—

  • A—

    B—

    R2  

     

    (1) wherein R1 denotes a phenyl, phenyl-C1-3-alkyl, phenyl-C2-4-alkenyl or naphthyl group, wherein in each case the aromatic moieties may be mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a C1-3-alkyl or C1-3-alkoxy group, while the substituents may be identical or different, a phenyl group, to which an n-propylene, n-butylene, methylenedioxy or ethylenedioxy bridge is fused via two adjacent carbon atoms, a phenyl group, to which a 5-membered heteroaromatic group is fused via two adjacent carbon atoms, which contains, in the heteroaromatic moiety, an imino group optionally substituted by a C1-3-alkyl group, an oxygen or sulphur atom, an imino group optionally substituted by a C1-3-alkyl group and an oxygen, sulphur or nitrogen atom, an imino group optionally substituted by a C1-3-alkyl group and two nitrogen atoms or an oxygen or sulphur atom and two nitrogen atoms, a pyridinyl or pyronyl group optionally substituted by a C1-3-alkyl group, to which a phenyl ring may be fused in each case via two adjacent carbon atoms, while in the abovementioned pyridine ring additionally a methine group in the 2 or 4 position may be replaced by a hydroxymethine group, A denotes a phenylene group optionally substituted by a C1-3-alkyl group, wherein in the aromatic moiety one, two or three methine groups may be replaced by nitrogen atoms, or a 5-membered heteroarylene group optionally substituted by a C1-3-alkyl group, while the heteroaromatic moiety is as hereinbefore defined, B denotes an —

    HN, —

    NH—

    CO, —

    CO—

    NH, —

    NH—

    CS or —

    CS—

    NH group, wherein the —

    NH group may be substituted in each case by a C1-3-alkyl group, and R2 denotes a C3-7-cycloalkyl or C4-7-cycloalkenyl group substituted by a carboxy group, a phenyl or naphthyl group substituted by a carboxy group, wherein in each case the aromatic moiety may be replaced by a nitro, amino, C1-3-alkylamino, di-(C1-3-alkyl)-amino, C1-3-alkanoylamino, N-(C1-3-alkyl)-C1-3-alkanoylamino or carboxy group, by an aminocarbonyl or C1-3-alkylaminocarbonyl group, wherein in each case the hydrogen atom of the aminocarbonyl group is monosubstituted by a C1-3-alkyl or C3-7-cycloalkyleneimino group, or is mono- or disubstituted by a fluorine, chlorine, bromine or iodine atom, by a C1-3-alkyl or C1-3-alkoxy group, while the substituents may be identical or different, a 5- or 6-membered heteroaryl group substituted by a carboxy group, while the 5-membered heteroaryl group is as hereinbefore defined and the 6-membered heteroaryl group contains one or two nitrogen atoms, or a straight-chain or branched C1-6-alkyl or C2-6-alkenyl group substituted by a carboxy group, while the carboxy groups mentioned in the definition of the abovementioned groups may additionally be replaced by a group which is converted in vivo into a carboxy group or is negatively charged under physiological conditions, and the imino or amino group mentioned in the definition of the abovementioned groups may be substituted by a group which can be cleaved in vivo, the isomers and the salts thereof.

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