Methods of endobronchial diagnosis using imaging

• US 20030055331A1
• Filed: 09/11/2002
• Published: 03/20/2003
• Est. Priority Date: 09/11/2001
• Status: Abandoned Application

• Current Assignee: Pulmonx Pulmonx
• Original Assignee: Pulmonx Pulmonx
• Inventors: Soltesz, Peter, Wondka, Anthony, Kotmel, Robert, Perkins, Rodney
• Application Number:
  US10/241,974
• Publication Number:
  US 20030055331A1
• Time in Patent Office: Days
• US Class Current: 600/410
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal

Abstract

Devices and methods are provided for acquiring and analyzing an image data file to generate diagnostic information reflecting an individual lung compartment. A lung compartment could be an entire lobe, a segment or a subsegment and beyond, hereinafter subsegments and beyond will be referred to simply as segments. Such analysis is used to assess the level of disease of individual lung compartments, both for quantification of the disease state and for determining the most appropriate treatment plan. This analysis allows the imaging technology to be used as a functional diagnostic tool as well as an anatomical diagnostic tool. To this end, dynamic data or images may also be acquired at specific points throughout the breathing cycle. Since air movement in and out of a lung compartment during the breathing cycle is a direct indicator of lung function in some diseases like emphysema, analysis of images during the breathing cycle will indicate levels of disease. Thus, a physician may be able to determine the nature of the disease, severity of the disease and the most effective course of treatment from a computerized image of the lung.

Claims

1. A method of analyzing data in an image data file of a lung comprising:

providing the image data file of the lung to a computer; and

analyzing the image data file on the computer with an algorithm which determines the periphery of at least one lung compartment within the lung.

2. A method as in claim 1, further comprising analyzing the image data with the computer using an algorithm which calculates the volume of the lung compartment.

3. A method as in claim 2, wherein analyzing the image data comprises:

defining voxels within the periphery of the lung compartment;

calculating the volume of each voxel; and

adding the volumes of the voxels together.

4. A method as in claim 1, further comprising analyzing the image data with the computer using an algorithm which determines the density of tissue in the lung compartment.

5. A method as in claim 4, wherein the algorithm correlates the image shade with density of the tissue.

6. A method as in claim 4, further comprising grading the lung compartment for level of emphysema based on the density of the tissue in the compartment.

7. A method as in claim 1, further comprising analyzing the image data with the computer using an algorithm which displays an image of the lung compartment isolated from the lung.

8. A method as in claim 1, wherein analyzing the image data comprises:

determining the density of the tissue at a first location within the lung;

determining the density of the tissue at a second location within the lung; and

comparing the density at the first location with the density at the second location to determine a difference in density,

wherein at least a portion of the periphery is based on a difference in density between the first and second locations above a density threshold value.

9. A method as in claim 1, wherein analyzing image data comprises:

identifying a lung passageway within the lung; and

determining the size of the lung passageway,

wherein at least a portion of the periphery of the lung compartment is based on the size of the passageway.

10. A method as in claim 1, wherein analyzing the image data comprises:

identifying an anatomical feature on the image which signifies a natural division between lung compartments,

wherein at least a portion of the periphery of the lung compartment is based on the location of the anatomical feature.

11. A method as in claim 1, wherein analyzing image data comprises:

determining a first periphery of a first lung compartment; and

determining a second periphery of a second lung compartment,

whereas the periphery of the lung compartment is based on the first and second peripheries.

12. A method as in claim 1, wherein providing the image data file involves scanning the lung with the use of computer tomography, magnetic resonance imaging, ultrasound, x-ray or positive emission tomography.

13. A method of generating an image data file of a lung of a patient at at least one preselected point in a breathing cycle, said method comprising:

providing a spirometer which generates pulmonary data representing a breathing cycle;

providing a controller which generates a signal at at least one point in a breathing cycle based on the pulmonary data;

providing an imaging device which is activated by the signal to create an image of the lung; and

breathing into the spirometer so that the pulmonary data is generated and the at least one signal is generated to activate the imaging device to create the image of the lung.

14. A method as in claim 13, wherein the image comprises an image data file.

15. A method as in claim 13, wherein the pulmonary data comprises a volumetric trace of a breathing cycle.

16. A method as in claim 13, wherein the controller generates a first signal at a first point in the breathing cycle so that a first image of the lung is created and a second signal at a second point in the breathing cycle so that a second image of the lung is created.

17. A method as in claim 16, further comprising calculating a quantitative difference in lung volume by comparing the first image with the second image.

18. A method as in claim 15, further comprising calculating at least one breathing volume from the volumetric trace wherein the breathing volume is selected from the group consisting of total lung capacity, vital capacity, inspiratory reserve volume, tidal volume, inspiratory capacity, expiratory reserve volume, functional residual capacity and residual volume.

19. A method as in claim 14, further comprising analyzing data in the image data file to determine the periphery of at least one lung compartment within the lung.

20. A method as in claim 19, further comprising calculating the volume of the lung compartment based on the image data file.

21. A method as in claim 20, wherein the further comprising calculating the volume of the lung, comparing the calculated volume of the lung with the total lung capacity, and calibrating the controller.