Method and apparatus for determining the cerebral state of a patient with fast response
First Claim
1. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method comprising the steps of:
- (a) obtaining EEG signal data from the patient;
(b) obtaining EMG signal data from the patient;
(c) analyzing a sample of sequential EEG signal data to obtain a first indication indicative of the cerebral state of the patient;
(d) analyzing a sample of sequential EMG signal data temporally related to the EEG signal data sample to obtain a second indication indicative of electromyographic activity in the patient; and
(e) producing a composite indication from the first and second indications obtained at steps (c) and (d) indicative of the cerebral state of the patient.
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Accused Products
Abstract
A method and apparatus for ascertaining the depth of anesthesia of the patient. In one embodiment, the entropy of the patient'"'"'s EEG signal data is determined as an indication of the depth of anesthesia. A frequency domain power spectrum quantity is obtained from the patient'"'"'s EMG signal data. The latter quantity can be updated more frequently than the EEG entropy due to its higher frequency. The EEG entropy indication and the EMG power spectrum indication can be combined into a composite indicator that provides an immediate indication of changes in the state of the patient. In a further embodiment, the frequency range over which the entropy of the biopotential signal from the patient is determined is selected to encompass both EEG signal data and EMG signal data and the entropy so determined used as an indication of the patients state. In addition, entropy of the EEG range alone can be used together with the entropy of the broadened range to indicate separately contributions from EEG and EMG. In a more generalized version of the further embodiment, a set of frequency components obtained from selected frequency ranges is utilized in determining entropy. The patient signal data from which the frequency components are extracted are obtained from time windows of differing lengths so that the resulting entropy indication will have optimally fast response times.
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Citations
123 Claims
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1. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method comprising the steps of:
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(a) obtaining EEG signal data from the patient;
(b) obtaining EMG signal data from the patient;
(c) analyzing a sample of sequential EEG signal data to obtain a first indication indicative of the cerebral state of the patient;
(d) analyzing a sample of sequential EMG signal data temporally related to the EEG signal data sample to obtain a second indication indicative of electromyographic activity in the patient; and
(e) producing a composite indication from the first and second indications obtained at steps (c) and (d) indicative of the cerebral state of the patient. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 47, 48, 49, 51, 52, 53, 54, 56, 58, 60, 62, 117)
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2. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method rapidly indicating changes in such state and comprising the steps of:
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(a) obtaining EEG signal data from the patient;
(b) obtaining EMG signal data from the patient, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of lower frequency;
(c) analyzing a sample of sequential EEG signal data to obtain a first indication indicative of the cerebral state of the patient, the length of a EEG signal data sample being such as to provide a cerebral state indication of desired accuracy;
(d) analyzing a sample of sequential EMG signal data temporally related to the EEG signal data sample to obtain a second indication indicative of electromyographic activity in the patient, it being possible to use a EMG signal data sample of shorter length than that of the EEG signal data sample due to the higher frequency of the EMG signal data; and
(e) producing a composite indication of the cerebral state of the patient from the first and second indications obtained at steps (c) and (d) indicative of the cerebral state of the patient, which composite indication can be updated at a repetition rate determined by the shorter sample length of the EMG signal data to rapidly indicate changes in the cerebral state of the patient.
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24. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method comprising the steps of:
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(a) obtaining biopotential signals from the patient, the biopotential signals containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of a lower frequency;
(b) analyzing a sample of sequential signal data over a frequency range that is sufficiently wide to include both the EEG and EMG signal data to obtain a measure of the complexity of the signal data; and
(c) providing the measure as an indication of the cerebral state of the patient. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 50, 55, 57, 59, 61, 63)
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25. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method rapidly indicating changes in such state and comprising the steps of:
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(a) obtaining biopotential signals from the patient, the biopotential signals containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of lower frequency;
(b) analyzing a sample of sequential signal data over a frequency range that is sufficiently wide to include both the EEG and EMG signal data to obtain a measure of the complexity of the signal data, it being possible to use a EMG signal data sample of shorter length than that of the EEG signal data sample due to the higher frequency of the EMG signal data; and
(c) providing the measure as an indication of the cerebral state of the patient, which indication can be updated at a repetition rate determined by the shorter sample length of the EMG signal data to rapidly indicate changes in the cerebral state of the patient.
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64. A method for ascertaining the depth of anesthesia of a patient, said method rapidly indicating changes in the hypnotic state of the patient and comprising the steps of:
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(a) obtaining biopotential signals from the patient, the biopotential signals containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of lower frequency;
(b) analyzing a sample of sequential signal data existing in a frequency range extending from a frequency of about 0.5 Hz to a frequency which is above 32 Hz to obtain a measure of the complexity of the signal data, it being possible to use a EMG signal data sample of shorter length than that of the EEG signal data sample due to the higher frequency of the EMG signal data;
(c) providing the complexity measure as a first indication of the cerebral state of the patient, which indication can be updated at a repetition rate determined by the shorter sample length of the EMG signal data to rapidly indicate changes in the cerebral state of the patient;
(d) analyzing a sample of EEG signal data to obtain a complexity measure of the EEG signal data;
(e) providing the complexity measure of the EEG signal data as a second indication of the cerebral state of the patient; and
(f) normalizing the first indication and second indication so that the first indication and second indication are equal in the absence of EMG signal data.
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65. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method comprising the steps of:
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(a) obtaining biopotential signal data from the patient, the biopotential signal data containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of a lower frequency;
(b) collecting the biopotential signal data over a plurality of time periods of differing lengths;
(c) subjecting the biopotential signal data of each of the time periods to spectral decomposition to obtain the frequency components of the collected biopotential signal data;
(d) selecting frequency components in a selected frequency band from the decomposed biopotential signal data for each of the time periods;
(e) analyzing the frequency components of a desired number of the frequency bands to obtain a measure of the complexity of the frequency components over a frequency range formed from the selected frequency bands; and
(f) providing the measure so obtained as an indication of the cerebral state of the patient. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85)
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86. A method for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said method comprising the steps of:
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(a) obtaining biopotential signal data from the patient, the biopotential signal data containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of a lower frequency;
(b) collecting the biopotential signal data over a plurality of time periods of differing lengths;
(c) subjecting the biopotential signal data of each of the time periods to decomposition to a set of basis function;
(d) selecting spectral components in a desired class of basis functions for each of the time periods;
(e) analyzing the spectral components of a desired number of the classes of basis functions to obtain a complexity measure of the spectral components from the desired number of classes of basis functions; and
(f) providing the measure so obtained as an indication of the cerebral state of the patient. - View Dependent Claims (87)
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88. Apparatus for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said apparatus comprising:
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(a) means for obtaining biopotential signals from the patient, the biopotential signals containing EEG signal data and EMG signal data;
(b) means analyzing a sample of sequential EEG signal data to obtain a first indicator indicative of the cerebral state of the patient and analyzing a sample of sequential EMG signal data temporally related to the EEG signal data sample to obtain a second indicator indicative of electromyographic activity in the patient; and
(c) means producing a composite indicator from the first and second indicators indicative of the cerebral state of the patient. - View Dependent Claims (89, 90, 91, 92, 93, 94, 104, 105, 106)
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95. Apparatus for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said apparatus comprising:
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(a) means for obtaining biopotential signals from the patient, the biopotential signals containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of a lower frequency;
(b) means for analyzing a sample of sequential signal data over a frequency range that is sufficiently wide to include both the EEG and EMG signal data to obtain a measure of the complexity of the signal data; and
(c) means providing the complexity measure as an indicator of the cerebral state of the patient. - View Dependent Claims (96, 97, 98, 99, 100, 101, 102, 103)
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107. Apparatus for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said apparatus comprising:
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(a) means for obtaining biopotential signal data from the patient, the biopotential signal data containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of a lower frequency;
(b) means for recording the biopotential signal data over a plurality of time periods of differing lengths;
(c) means for spectrally decomposing the biopotential signal data of each of the time periods to obtain the frequency components of the collected biopotential signal data;
(d) means for selecting frequency components in a selected frequency band from the decomposed biopotential signal data for each of the time periods;
(e) means analyzing the frequency components of a desired number of the frequency bands to obtain a measure of the complexity of the frequency components over a frequency range formed from the selected frequency bands; and
(f) means providing the measure so obtained as an indication of the cerebral state of the patient. - View Dependent Claims (108, 109, 110, 111, 112, 113, 114, 115, 116, 118, 119, 120, 121)
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122. Apparatus for ascertaining the cerebral state of a patient, including a state resulting from the administration of a drug, said apparatus comprising:
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(a) means for obtaining biopotential signal data from the patient, the biopotential signal data containing EEG signal data and EMG signal data, the EMG signal data being primarily of a higher frequency than the EEG signal data which is primarily of a lower frequency;
(b) means for recording the biopotential signal data over a plurality of time periods of differing length;
(c) means for subjecting the biopotential signal data of each of the time periods to decomposition to a set of basis function;
(d) means for selecting spectral components in a desired class of basis functions for each of the time periods;
(e) means analyzing the spectral components of a desired number of the classes of basis functions to obtain a complexity measure of the spectral components from the desired number of classes of basis function; and
(f) means for providing the measure so obtained as an indication of the cerebral state of the patient. - View Dependent Claims (123)
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Specification