Minimally invasive sensing system for measuring rigidity of anatomical matter

• US 20030055360A1
• Filed: 09/04/2002
• Published: 03/20/2003
• Est. Priority Date: 09/05/2001
• Status: Abandoned Application

• Current Assignee: Verimetra, Inc.
• Original Assignee: Verimetra, Inc.
• Inventors: Stone, Curtis, Rebello, Keith, Zeleznik, Matthew A., Migliuolo, Michele, Gabriel, Kaigham J., Lebouitz, Kyle S.
• Application Number:
  US10/233,565
• Publication Number:
  US 20030055360A1
• Time in Patent Office: Days
• US Class Current: 600/587
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/103 Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes A61B5/08 takes precedence; measuring aids for tailors A41H1/00; measuring instruments specially adapted for dentistry A61C19/04
• CPC Class Codes: A61B 5/6847 mounted on an invasive device
• CPC Class Codes: A61B 5/6885 Monitoring or controlling sensor contact pressure

Abstract

Apparatus are provided for determining relative and absolute properties of anatomical matter, such as biological tissue including arteries as well as other surgical and medical materials. An illustrative apparatus includes a probe for probing the properties of the anatomical matter. The probe includes a probe shaft having a sense rod, where the sense rod has a proximal end and a distal end, and where the distal end has a probe tip that is configured to contact and probe the anatomical matter. The probe also includes a sensor in mechanical communication with the sense rod, where the sensor is configured to at least measure tissue relative tissue rigidity and/or absolute tissue rigidity, including rigidity of a material on an interior surface of the tissue, a fluid flow rate in an interior of the tissue, a fluid pressure in an interior of the tissue, and/or a viscosity of a fluid in an interior of the tissue. The probe optionally includes a temperature sensor in thermal communication with the probe tip, where the thermal sensor can provide additional data, such as data related to inflammation of the tissue. Methods for probing the rigidity and other physical properties of the anatomical matter are also provided.

Claims

1. A probe for probing rigidity of anatomical matter, the probe comprising:

a probe shaft comprising a sense rod, wherein the sense rod has a proximal end and a distal end, wherein the distal end comprises a probe tip configured to contact the anatomical matter; and

a sensor in mechanical communication with the sense rod, wherein the sensor can at least make a measurement chosen from a group consisting of a measurement of the rigidity of the anatomical matter, a measurement of a change in the rigidity of the anatomical matter, a measurement of a rigidity of a material on an interior surface of the anatomical matter, a fluid flow rate in an interior of the anatomical matter, a fluid pressure in an interior of the anatomical matter, a viscosity of a fluid in an interior of the anatomical matter, and any combination of thereof.

2. The probe according to claim 1, wherein the distal end of the sense rod can fit into an incision used in minimally invasive surgery.

3. The probe according to claim 1, wherein the probe shaft is elongated and has sufficient longitudinal rigidity to minimize or eliminate bending or buckling during probing.

4. The probe according to claim 1, wherein the sensor is located in the probe tip.

5. The probe according to claim 1, wherein the sensor is not located in the probe tip.

6. The probe according to claim 1, wherein the sensor comprises a microelectromechanical system.

7. The probe according to claim 6, wherein the microelectromechanical system comprises a sensor selected from a group consisting of a pressure sensor, a capacitive sensor, a displacement sensor, a strain sensor, and any combination thereof.

8. The probe according to claim 1, wherein the probe further comprises a temperature sensor in thermal communication with the probe tip.

9. The probe according to claim 1, wherein the sensor is a microelectromechanical pressure sensor.

10. The probe according to claim 6, wherein the probe further comprises:

an adapter tube connected to the distal end of the sense rod;

a bellows connected to the adapter tube; and

an adaptor ring connected to the bellows.

11. The probe according to claim 10, wherein the probe further comprises an outer support tube having a low-friction interior surface that at least partially extends over the proximal end of the sense rod, wherein the outer support tube is connected to the adaptor ring and has an interior diameter small enough to minimize off-axis deflection of the sense rod and large enough to not restrict motion of the sense rod.

12. The probe according to claim 10, wherein the probe can make a bellows measurement selected from a group consisting of a displacement measurement of the bellows, a compression measurement of the bellows, a decompression measurement of the bellows, and any combination thereof.

13. The probe according to claim 10, wherein the probe comprises a sealed chamber defined on at least one side by the bellows, and a pressure in the seal chamber is changed by compression of the bellow, decompression of the bellows, or both;

and

wherein the sensor can make a pressure measurement selected from a group consisting of a measurement of the pressure in the sealed chamber, a measurement of a change of the pressure in the sealed chamber, and any combination thereof.

14. The probe according to claim 10, wherein the sensor comprises a capacitance sensor that can detect a deflection of the bellows.

15. The probe according to claim 10, wherein the sensor comprises a displacement sensor configured to detect a displacement of the bellows.

16. The probe according to claim 10, wherein the sensor comprises a strain sensor that can make a bellows measurement selected from a group consisting of a bellows compression measurement, a bellows decompression measurement, and any combination thereof.

17. The probe according to claim 1, wherein the probe further comprises an actuator in mechanical communication with the probe, and wherein the actuator can actuate a position of the probe, the sense rod, or any combination thereof.

18. The probe according to claim 17, wherein the actuator comprises an actuator chosen from a group consisting of a piezoelectric actuator, a robotic surgical system, a pneumatic actuator, an inductively driven actuator, a magnetic actuator, an electromagnetic actuator, a micropositioner, and any combination thereof.

19. The probe according to claim 17, wherein the actuator can make an actuation chosen from a group consisting of an oscillation of the position of the sense rod, a pulsing of the position of the sense rod, and any combination thereof.

20. The probe according to claim 19, wherein the sensor comprises a sensor that can make a measurement of an element, wherein the element is chosen from a group consisting of the actuator, the sense rod, and any combination thereof, and wherein the measurement is chosen from a group consisting of a measurement of an oscillation frequency, a measurement of an oscillation amplitude, a measurement of an oscillation phase, a measurement of pulse-echo delay, a measurement of pulse-echo amplitude, a measurement of pulse-echo waveform shape, a change in any foregoing measurement, and any combination thereof.

21. The probe according to claim 19, wherein the sensor at least can make a measurement of the actuator, wherein the measurement is chosen from a group consisting of an oscillation frequency, an oscillation amplitude, an oscillation phase, a pulse-echo delay, a pulse-echo amplitude, an electrical resistance, an electrical capacitance, an electrical inductance, an electrical current, an electrical voltage, a magnetic field of the actuator, any change in the foregoing, and any combination thereof.

22. The probe according to claim 1, further comprising a point contact sensor in mechanical communication with the probe tip.

23. The probe according to claim 22, wherein the point contact sensor comprises a sensor selected from a group consisting of an ultrasonic sensor, a membrane switch, a fluid pressure sensor, a temperature based sensor, and any combination thereof.

24. The probe according to claim 1, wherein the probe tip is detachable from the sense rod.

25. The probe according to claim 1, wherein the probe tip can be substantially sterilized for medical applications.

26. A method for probing rigidity of anatomical matter, comprising:

contacting the anatomical matter with a probe comprising

a probe shaft comprising a sense rod, wherein the sense rod has a proximal end and a distal end, wherein the distal end comprises a probe tip configured to contact the anatomical matter, and

a sensor in mechanical communication with the sense rod, wherein the sensor can make a measurement chosen from a measurement of the rigidity of the anatomical matter, a measurement of a change in the rigidity of the anatomical matter, a measurement of a rigidity of a material on an interior surface of the anatomical matter, a fluid flow rate in an interior of the anatomical matter, a fluid pressure in an interior of the anatomical matter, a viscosity of a fluid in an interior of the anatomical matter, and any combination of thereof,

wherein the contacting comprises contacting the anatomical matter with the probe tip;

displacing the probe relative to the surface; and

determining the rigidity of the anatomical matter based on at least a signal generated from the sensor.

27. A method according to claim 26, wherein the determining comprising making a signal analysis chosen from a group consisting of an analysis of an amplitude of the signal, an analysis of a change in the signal as a function of probe displacement, an analysis of a rate of change of the signal, an analysis of the signal relative to a calibration signal, and any combination thereof.

28. A method according to claim 26, wherein the probe further comprises a temperature sensor and the signal from the sensor in mechanical communication with the sense rod is temperature compensated.

29. A method for probing an interior surface of anatomical matter, comprising:

contacting the anatomical matter with a probe comprising

a probe shaft comprising a sense rod, wherein the sense rod has a proximal end and a distal end, wherein the distal end comprises a probe tip configured to contact the anatomical matter,

a first sensor in mechanical communication with the sense rod, wherein the sensor can make a measurement chosen from a measurement of the rigidity of the anatomical matter, a measurement of a change in the rigidity of the anatomical matter, a measurement of a rigidity of a material on an interior surface of the anatomical matter, a fluid flow rate in an interior of the anatomical matter, a fluid pressure in an interior of the anatomical matter, a viscosity of a fluid in an interior of the anatomical matter, and any combination of thereof, and

a temperature sensor in thermal communication with the probe tip,

wherein the contacting comprises contacting the anatomical matter with the probe tip;

determining information related to the interior surface of the anatomical matter based on at least a signal generated from the first sensor; and

determining a temperature of the anatomical matter based on at least a signal generated from the temperature sensor.

30. The method according to claim 29, wherein the anatomical matter is an artery, and wherein the information related to the interior surface of the artery comprises information related to plaque components on the interior surface of the artery based on a signal generated from the first sensor.

31. The method according to claim 29, wherein the anatomical matter is an artery, and wherein the method comprises determining information related to inflammation of the artery based on at least the determining the temperature of the artery.