Feed additive compositions and methods
First Claim
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1. An improved feed for production animals, comprising one or more plant-derived feed ingredients, substantially unsupplemented with small-molecule antibiotics, and as an additive a seed composition containing a flour, extract, or malt obtained from mature monocot seeds and one or more heterologous seed-produced anti-microbial proteins in substantially unpurified form.
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Abstract
The invention is directed to improved animal feed compositions comprising one or more milk proteins produced in the seeds of a transgenic plant and methods of making and using the same.
49 Citations
37 Claims
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1. An improved feed for production animals, comprising
one or more plant-derived feed ingredients, substantially unsupplemented with small-molecule antibiotics, and as an additive a seed composition containing a flour, extract, or malt obtained from mature monocot seeds and one or more heterologous seed-produced anti-microbial proteins in substantially unpurified form.
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10. In a method for achieving high growth rates in production animals, by feeding animals a feed supplemented with sub-therapeutic levels of one or more small-molecule antibiotics, an improvement comprising
replacing the small-molecule antibiotic(s) in the feed with a seed composition containing a flour, extract, or malt obtained from mature monocot seeds and one or more seed-produced heterologous anti-microbial proteins in substantially unpurified form.
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16. A method of producing a feed for production animals, comprising
(a) obtaining a monocot plant that has been stably transformed with a first chimeric gene having (i) a transcriptional regulatory region from a monocot gene having a seed maturation-specific promoter, (ii) operably linked to said transcriptional regulatory region, a leader DNA sequence encoding a monocot seed-specific transit sequence capable of targeting a linked polypeptide to an endosperm-cell organelle, and (iii) a protein-coding sequence encoding a heterologous anti-microbial protein, (b) cultivating the transformed plant under seed-maturation conditions, (c) harvesting mature seeds from the cultivated plant, (d) extracting from the harvested seeds, a flour, extract, or malt composition containing the human milk protein in substantially unpurified form, and (e) adding the composition to an animal feed that is substantially free of small-molecule antibiotics.
Specification