Method for treating lung cancers

• US 20030059375A1
• Filed: 08/20/2002
• Published: 03/27/2003
• Est. Priority Date: 08/20/2001
• Status: Abandoned Application

• Current Assignee: Transave Inc. (Insmed Incorporated)
• Original Assignee: Transave Inc. (Insmed Incorporated)
• Inventors: Perez-Soler, Roman, Pilkiewicz, Frank
• Application Number:
  US10/224,293
• Publication Number:
  US 20030059375A1
• Time in Patent Office: Days
• US Class Current: 424/45
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0073 Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1277 Processes for preparing; Proliposomes
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/04 specific for metastasis

Abstract

A method of treating bronchoalveolar carcinoma, carcinomatosis with lymphangitic spread or primary and metastatic lung cancers by administering one or more bioactive agents by inhalation of a lipid composition. The one or more bioactive agents preferably comprise cisplatin, carboplatin or a taxane.

Claims

1. A method of treating bronchoalveolar carcinoma, carcinomatosis with lymphangitic spread or primary and metastatic lung cancers, the method comprising administering one or more bioactive agents by inhalation of a lipid composition.

2. The method of claim 1, wherein the one or more bioactive agents comprise cisplatin, oxaliplatin, carboplatin or a taxane.

3. The method of claim 1, wherein the one or more bioactive agents comprise cisplatin.

4. The method of claim 1, wherein the one or more bioactive agents comprise carboplatin.

5. The method of claim 1, wherein the one or more bioactive agents comprise oxaliplatin.

6. The method of claim 1, wherein the one or more bioactive agents comprise a taxane.

7. The method of claim 6, wherein the taxane is paclitaxel.

8. The method of claim 6, wherein the taxane is docetaxel.

9. The method of claim 1, wherein the lipid composition is a liposome.

10. The method of claim 1, wherein the step of administering the lipid composition comprises nebulizing the lipid composition and delivering resulting particles to the lungs of a patient.

11. The method of claim 10, wherein the particles are between 0.5 and 10 microns in diameter.

12. The method of claim 10 wherein the particles are between 1 and 2 microns in diameter.