Antibodies that immunospecifically bind BLyS
First Claim
1. An antibody that immunospecifically binds to BLyS comprising a first amino acid sequence at least 95% identical to an second amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence comprising the amino acid sequence of a VHCDR of any one of the scFvs of SEQ ID NOS;
1 through 2128; and
(b) an amino acid sequence comprising the amino acid sequence of a VLCDR of any one of the scFvs of SEQ ID NOS;
1 through 2128.
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Accused Products
Abstract
The present invention relates to antibodies and related molecules that immunospecifically bind to BLyS. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant BLyS expression or inappropriate function of BLyS comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS expression or inappropriate BLyS function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS.
150 Citations
96 Claims
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1. An antibody that immunospecifically binds to BLyS comprising a first amino acid sequence at least 95% identical to an second amino acid sequence selected from the group consisting of:
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(a) an amino acid sequence comprising the amino acid sequence of a VHCDR of any one of the scFvs of SEQ ID NOS;
1 through 2128; and
(b) an amino acid sequence comprising the amino acid sequence of a VLCDR of any one of the scFvs of SEQ ID NOS;
1 through 2128. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 84, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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81. An antibody that competitively inhibits the binding of the antibody produced by the cell line having ATCCDeposit Number PTA-3239.
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82. An antibody that competitively inhibits the binding of the antibody produced by the cell line having ATCCDeposit Number PTA-3240
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83. An antibody that competitively inhibits the binding of the antibody produced by the cell line having ATCCDeposit Number PTA-3243.
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85. An antibody that immunospecifically binds to BLyS, said antibody comprising an amino acid sequence of a VH domain encoded by a nucleotide sequence that hybridizes under stringent conditions to a nucleotide sequence encoding a VH domain of an scFv comprising an amino acid sequence of any one of SEQ ID NOS:
- 1 to 2128.
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86. An antibody that immunospecifically binds to BLyS, said antibody comprising an amino acid sequence of a VL domain encoded by a nucleotide sequence that hybridizes under stringent conditions to a nucleotide sequence encoding a VL domain from an scFv comprising an amino acid sequence of any one of SEQ ID NOS:
- 1 to 2128.
Specification