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Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies

  • US 20030059939A1
  • Filed: 08/27/2002
  • Published: 03/27/2003
  • Est. Priority Date: 08/27/2001
  • Status: Active Grant
First Claim
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1. A method for effecting trans-differentiation of a somatic cell comprising (a) culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation;

  • (b) culturing the cell in the presence of agents or conditions that induce differentiation to a cell type different than that of said somatic cell; and

    (c) allowing the cell to trans-differentiate to said different cell type.

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