×

Cell activation process and reagents therefor

  • US 20030060444A1
  • Filed: 10/24/2002
  • Published: 03/27/2003
  • Est. Priority Date: 06/25/1997
  • Status: Abandoned Application
First Claim
Patent Images

1. A method of activating a cell as a result of one type of extracellular interaction between said first cell and a molecule associated with a second target cell characterised in that said first cell is provided with a DNA delivery system comprising DNA coding for one or more recombinant chimeric receptors comprising two or more different cytoplasmic signalling components, wherein said cytoplasmic components are not naturally linked, and at least one is derived from a membrane spanning polypeptide, characterised in that at least one of said cytoplasmic signalling components is a co-stimulatory signalling domain derived from all or part of a tetra-span-transmembrane protein, CD43, CD6, a mannose, IL-7, IL-12 or complement receptor, an integrin-associated protein, or a γ

  • -chain associated with a cytokine receptor.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×